• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genomics >Exploring the correlation between deltamethrin stress and Keap1-Nrf2-ARE pathway from Drosophila melanogaster RNASeq data
【24h】

Exploring the correlation between deltamethrin stress and Keap1-Nrf2-ARE pathway from Drosophila melanogaster RNASeq data

机译：探索溴氰菊酯和Keap1-NRF2之间的相关性来自果蝇Melanogaster RNASEQ数据的途径

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Deltamethrin (DM) is widely used in a variety of pest control, resulting in serious drug resistance. Keap1-Nrf2-ARE is the antioxidant stress pathway. We identified 268 genes differentially expressed (DEGs) in Drosophila Kc cells treated with DM, including up-regulated 180 genes and down-regulated 88 genes compared with the control group (fold-change≥2, qValue≤0.001) by RNA-seq, they are mainly linked to metabolic process, stimulation response, immune system process. When the cells are treated with DM in the case of overexpression of the Keap1 gene, the cytochrome P450 family genes were significantly down-regulated, and some diseases-related genes and non-coding genes also changed. Our data shown that Keap1-Nrf2-ARE pathway may play an important role in DM stress, which will provide a new direction for studying the mechanism of insect resistance.
机译：溴氰菊酯（DM）广泛用于各种害虫控制，导致严重的耐药性。 Keap1-NRF2-是抗氧化应力途径。我们鉴定了DM处理的果蝇KC细胞中的268个基因差异表达（DEGS），包括上调的180个基因和下调的88个基因，与RNA-SEQ的对照组（折叠变化≥2，qValue≤0.001）相比，它们主要与代谢过程，刺激反应，免疫系统过程相关联。当在keap1基因过表达的情况下用DM处理细胞时，细胞色素p450家族基因显着下调，并且一些疾病相关基因和非编码基因也发生了变化。我们的数据显示，Keap1-NRF2是途径可能在DM压力中发挥重要作用，这将为研究抗虫机制提供新的方向。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号