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首页> 外文期刊>Genomics >The first evidence of an association between a polymorphism in the endocannabinoid-degrading enzyme FAAH (FAAH rs2295633) with attention deficit hyperactivity disorder
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The first evidence of an association between a polymorphism in the endocannabinoid-degrading enzyme FAAH (FAAH rs2295633) with attention deficit hyperactivity disorder

机译：具有注意力缺陷多动障碍的内突造黄油降解酶（FAAH RS2295633）中多态性之间的关联的第一种证据

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Several single nucleotide polymorphisms (SNPs) of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the endocannabinoids, have been shown to be associated with many neuropsychiatric disorders. Here, FAAH rs2295633 was studied in ADHD and case-control healthy children. There was a significant difference in the allele frequency (P?=?.04) and genotype distribution (P?=?.04) of the FAAH rs2295633 between ADHD cases and controls. The ADHD children appeared to have less of TT genotype (OR 0.396, 95% CI 0.178–0.884, p?=?.024) and T allele (OR 0.658, 95% CI 0.440–0.982, p?=?.04). To our best knowledge, this is the first statistical significant association between FAAH rs2295633 genotype and ADHD disorder. Larger sample sizes and functional studies are warranted to explore the clinical utility of FAAH genotyping as a possible marker for increased ADHD risk in children.
机译：已经显示出脂肪酸酰胺水解酶（FAAH）的几种单一核苷酸多态性（SNP），内致植物蛋白的降解酶，许多神经精神障碍有关。在此，在ADHD和案例控制健康儿童中研究了FAAH RS2295633。等位基因频率（p？=β.04）和FAAH RS2295633之间的等位基频率（P？= 04）和基因型分布（P？=〜04）之间存在显着差异。 ADHD儿童似乎具有较少的TT基因型（或0.396,95％CI 0.178-0.884，P？=β.024）和T等位基因（或0.658,95％CI 0.440-0.982，P？= 04）。为了我们的最佳知识，这是FAAH RS2295633基因型和ADHD疾病之间的第一个统计重大关联。需要更大的样本尺寸和功能研究，以探讨FAAH基因分型作为可能标记的临床效用，以增加儿童的ADHD风险。

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