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首页> 外文期刊>Genomics >Genome-wide CNV analysis revealed variants associated with growth traits in African indigenous goats
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Genome-wide CNV analysis revealed variants associated with growth traits in African indigenous goats

机译：基因组 - 宽的CNV分析显示出与非洲土着山羊的生长性状相关的变体

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Using the CaprineSNP50 data generated by the AGIN consortium, we detected common CNVs in 126 samples from four African indigenous goat breeds. A total of 30 CNVs ranging from 30,237?bp to 4,910,757?bp were identified. These CNVs were then associated with six growth traits by a linear regression analysis. Three significant associations were identified between two CNVs and two body traits after false discovery rate (FDR) correction (P??.05). One of them (CNV27) was significantly associated with both chest width and width of pin bones. It overlaps the SNX29 gene, the Gene Ontology (GO) annotations of which indicate CNV27 could be a potential functional candidate for meat production, health and reproduction traits. To our knowledge, this study is the first CNV-based association test of growth traits using SNP chip data in African meat goats.
机译：使用AGIN联盟产生的Caprinesnp50数据，我们检测到来自四个非洲土着山羊品种的126个样本中的常见CNV。总共30个CNV，范围从30,237？BP到4,910,757磅？BP。然后通过线性回归分析与六个生长特征相关联。在错误发现率（FDR）校正后，在两个CNV和两个体状性质之间鉴定了三个重要关联（P？<β.05）。其中一个（CNV27）与夹骨宽度和宽度宽度显着相关。它与SNX29基因重叠，基因本体（GO）注释表明CNV27可以是肉类生产，健康和生殖特征的潜在功能候选者。据我们所知，本研究是使用非洲肉山羊中的SNP芯片数据的第一个基于CNV的生长性状的基于CNV的结合测试。

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