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首页> 外文期刊>Genomics >Identifying FL11 subtype by characterizing tumor immune microenvironment in prostate adenocarcinoma via Chous 5-steps rule
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Identifying FL11 subtype by characterizing tumor immune microenvironment in prostate adenocarcinoma via Chous 5-steps rule

机译：通过对同伴的5步规则表征前列腺腺癌中肿瘤免疫微环境的鉴定FL11亚型

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Prostate cancer is one of the leading causes of death in men worldwide, revealing a substantial heterogeneity in terms of molecular and clinical behaviors. Tumor infiltrating immune cell is associated with prognosis and response to immunotherapy in several cancer types. However, until now, the immune infiltrate profile of distinct subtypes for prostate cancer remains poorly characterized. In this study, using immune infiltration profiles as well as transcriptomic datasets, we characterized this subtype of prostate tumors. We observed that the FLI1 subtype of prostate tumors was highly enriched in immune system processes, immune related KEGG pathways and biological processes. We also expanded this approach to explore the immune infiltration profile of the high FLI1 expression subtype for skin cutaneous melanoma, similar results were found. Investigation of the association of immune infiltration features with the FLI1 expression demonstrated that many important features were associated with the FLI1 expression.
机译：前列腺癌是全世界男性死亡原因之一，在分子和临床行为方面揭示了重要的异质性。肿瘤浸润免疫细胞与预后和对几种癌症类型的免疫疗法的反应有关。然而，到目前为止，前列腺癌的不同亚型的免疫渗透概况表现不佳。在该研究中，使用免疫渗透型材以及转录组数据集，我们表征了前列腺肿瘤的这种亚型。我们观察到，前列腺肿瘤的FLI1亚型高度富集免疫系统方法，免疫相关KEGG途径和生物过程。我们还扩大了这种方法来探讨皮肤皮肤瘤的高FLI1表达亚型的免疫渗透谱，发现类似的结果。对FLI1表达的免疫渗透特征的调查表明，许多重要特征与FLI1表达有关。

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