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首页> 外文期刊>Genomics >Identification and characterization of circular RNA in lactating mammary glands from two breeds of sheep with different milk production profiles using RNA-Seq
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Identification and characterization of circular RNA in lactating mammary glands from two breeds of sheep with different milk production profiles using RNA-Seq

机译：使用RNA-SEQ具有不同牛奶生产谱系哺乳哺乳动物循环乳腺循环RNA的鉴定与表征

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摘要

CircRNA is a specific type of non-coding RNA that has been shown to have an important role in mammary gland (MG) activity, but no study of MG circRNA activity in sheep so far. In this study, the expression profile of circRNAs was investigated using RNA-Seq in MG parenchyma at peak lactation from Small-Tailed Han sheep and Gansu Alpine Merino sheep with phenotypic differences in milk yield and components. A total of 4, 906 circRNAs were found and 33 of these were differentially expressed between breeds. GO and KEGG results showed that the parental genes of differentially expressed circRNAs were mainly enriched in heterocyclic compound binding, kinase activity, adherens junction, the TGF-β signaling pathway, and the MAPK signaling pathway. This study provides an overview of circRNA expression in the ovine MG and the interaction between some key circRNAs and their target miRNAs. It improves our knowledge of the role of circRNA in sheep milk synthesis.
机译：Circrna是一种特定类型的非编码RNA，已被证明在乳腺（Mg）活性中具有重要作用，但是目前绵羊中的Mg CircrNA活性没有研究。在这项研究中，在小尾汉羊和甘肃高山美奴羊的峰泌乳中，使用RNA-SEQ在Mg疾病中，在牛奶产量和组分的表型差异，使用RNA-SEQ在MG实质中的峰泌乳中研究了CircrNA的表达谱。发现共有4,906个CircrNA，其中33种在品种之间差异表达。 Go和Kegg结果表明，差异表达的CircRNA的父母基因主要富含杂环化合物结合，激酶活性，粘附结，TGF-β信号通路和MAPK信号通路。本研究概述了绵羊MG中的CircrNA表达以及一些关键芯片与其目标miRNA之间的相互作用。它提高了我们对Circrna在羊牛奶合成中的作用的了解。

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