...
首页> 外文期刊>Genomics >Single-cell alternative splicing analysis reveals dominance of single transcript variant
【24h】

Single-cell alternative splicing analysis reveals dominance of single transcript variant

机译:单细胞替代剪接分析揭示了单一转录变体的主导地位

获取原文
           

摘要

Alternative splicing contributes to the diversity of gene products by producing multiple transcript variants from one gene. Previous studies have revealed highly variable splicing patterns in single cells, but there is still a controversy in the understanding of the simultaneous expression of multiple transcript variants. Here we show that the dominance of a single transcript variant is a common phenomenon in single cells. We analyzed several single-cell RNA sequencing datasets and observed consistent results. Our results demonstrate that single cells tend to express one major transcript variant of a gene, and the diversity of transcript variants in cell populations mainly results from the heterogeneity of splicing pattern in single cells.
机译:替代剪接通过从一种基因产生多个转录物变体而导致基因产物的多样性。以前的研究揭示了单个细胞中具有高度可变的剪接模式,但是在理解多发性转录变体的同时表达时仍然存在争议。在这里,我们表明单个转录变体的优势是单细胞中的常见现象。我们分析了几个单细胞RNA测序数据集并观察到一致的结果。我们的结果表明,单细胞倾向于表达基因的一个主要转录变体,细胞群中的转录物变体的多样性主要是由单细胞中剪接图案的异质性产生的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号