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Molecular pathology of human knee arthrofibrosis defined by RNA sequencing

机译：通过RNA测序定义人膝部关节刺激的分子病理

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Arthrofibrosis is an abnormal histopathologic response, is debilitating for patients, and poses a substantial unsolved clinical challenge. This study characterizes molecular biomarkers and regulatory pathways associated with arthrofibrosis by comparing fibrotic and non-fibrotic human knee tissue. The fibrotic group encompasses 4 patients undergoing a revision total knee arthroplasty (TKA) for arthrofibrosis (RTKA-A) while the non-fibrotic group includes 4 patients undergoing primary TKA for osteoarthritis (PTKA) and 4 patients undergoing revision TKA for non-arthrofibrotic and non-infectious etiologies (RTKA-NA). RNA-sequencing of posterior capsule specimens revealed differences in gene expression between each patient group by hierarchical clustering, principal component analysis, and correlation analyses. Multiple differentially expressed genes (DEGs) were defined in RTKA-A versus PTKA patients (i.e., 2059 up-regulated and 1795 down-regulated genes) and RTKA-A versus RTKA-NA patients (i.e., 3255 up-regulated and 3683 down-regulated genes). Our findings define molecular and pathological markers of arthrofibrosis, as well as novel potential targets for risk profiling, early diagnosis and pharmacological treatment of patients.
机译：关节纤维化是一种异常的组织病理学反应，对患者进行了衰弱，并造成了大量未解决的临床挑战。本研究通过比较纤维化和非纤维化人膝组织来表征与关节纤维化相关的分子生物标志物和调节途径。纤维化组包括4例经历过膝关节关节置换术（TKA）的患者，用于关节纤维化（RTKA-A），而非纤维分子组包括4名接受骨关节炎（PTKA）的初级TKA的患者，并为非关节纤维化和4名接受修订TKA进行修订的患者非传染性病因（RTKA-NA）。后胶囊标本的RNA测序显示通过分层聚类，主成分分析和相关分析对每个患者组之间的基因表达的差异。在RTKA-A与PTKA患者（即2059个上调和1795个下调基因）和RTKA-A与RTKA-NA患者（即3255升调和3683下调）中定义多种差异表达基因（IEGS）。受调节基因）。我们的发现定义了促触发的分子和病​​理标志物，以及对患者的风险分析，早期诊断和药理治疗的新潜在目标。

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