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首页> 外文期刊>Gut and Liver >Mesenchymal Stem Cells Decrease Oxidative Stress in the Bowels of Interleukin-10 Knockout Mice
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Mesenchymal Stem Cells Decrease Oxidative Stress in the Bowels of Interleukin-10 Knockout Mice

机译：间充质干细胞在白细胞介素-10敲除小鼠的肠道中降低氧化应激

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Background/Aims Inflammatory bowel disease (IBD) is an autoimmune disease characterized by chronic inflammation mainly in the large intestine. The interleukin-10 knockout (IL-10 KO) mouse is a well-known animal model of IBD that develops spontaneous intestinal inflammation resembling Crohn’s disease. Oxidative stress is considered to be the leading cause of cell and tissue damage. Reactive oxygen species (ROS) can cause direct cell injury and/or indirect cell injury by inducing the secretion of cytokines from damaged cells. This study evaluated the effects of mesenchymal stem cell (MSC) on the progression of IBD. Methods In this study, human bone marrow-derived MSCs were injected into IL-10 KO mice (MSC). Oxidative stress and inflammation levels were evaluated in the large intestine and compared with those in control IL-10 KO mice (CON) and normal wild-type control mice (Wild). Results The levels of ROS (superoxide and hydrogen peroxidase) and a secondary end-product of lipid peroxidation (malondialdehyde) were considerably higher in the CON, while superoxide dismutase and catalase levels were lower in the MSC. Inflammation-related marker (interferon-γ, tumor necrosis factor-α, IL-4, and CD8) expression and inflammatory histological changes were much less pronounced in MSC than in CON. Conclusions MSCs affect the redox balance, leading to the suppression of IBD.
机译：背景/ AIMS炎性肠病（IBD）是一种自身免疫性疾病，其特征在于慢性炎症，主要是在大肠中。白细胞介素-10敲除（IL-10 KO）小鼠是一种众所周知的IBD动物模型，其具有类似克罗恩病的自发肠炎症。氧化应激被认为是细胞和组织损伤的主要原因。反应性氧物质（ROS）可引起直接细胞损伤和/或间接细胞损伤通过诱导受损细胞的细胞因子的分泌。该研究评估了间充质干细胞（MSC）对IBD进展的影响。方法在本研究中，将人骨髓衍生的MSC注入IL-10 KO小鼠（MSC）中。在大肠中评价氧化应激和炎症水平，与对照IL-10 KO小鼠（CON）和正常野生型对照小鼠（野生）的炎症水平进行比较。结果CON脂质过氧化（丙二醛）的ROS（超氧化物和氢过氧化物酶）和二级末端产物的水平相当高，而MSC的超氧化物歧化酶和过氧化氢酶水平较低。与炎症相关的标记（干扰素-γ，肿瘤坏死因子-α，IL-4和CD8）表达和炎症组织学变化在MSC中比在CON中低得多。结论MSCS影响氧化还原平衡，导致抑制IBD。

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