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首页> 外文期刊>Folia histochemica et cytobiologica >JAK2 mutation status, hemostatic risk factors and thrombophilic factors in essential thrombocythemia (ET) patients
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JAK2 mutation status, hemostatic risk factors and thrombophilic factors in essential thrombocythemia (ET) patients

机译：jak2突变状态，止血危险因素和基本血小板血症（et）患者的血栓形成因素

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The recently discovered JAK2 V617F point mutation, found in 50–60% of ET patients, has been reported to be associated with a higher risk of thrombotic events. In this study, we explored if JAK2 V617F mutation, or coexisting thrombophilic and hemostatic risk factors, contributed to these complications. We examined 32 patients with ET, and looked for pathogenetic JAK2 V617F mutation and prothrombotic genes mutations: factor V Leiden, prothrombin and MTHFR. We also evaluated plasma levels of fibrinogen, factors VIII and XII, AT, protein C, protein S and serum level of homocysteine. Urokinase concentration was assessed in patients’ plasma as well as platelet lysates. There was no difference in the number of thrombotic complications between ET patients with and without JAK2 mutation. However, we found a number of thrombophilic and hemostatic risk factors that could contribute to thrombotic complications in ET patients. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 2, pp. 267–271)
机译：据报道，最近发现的jak2 v617f点突变在50-60％的ET患者中发现，血栓形成事件的风险较高。在这项研究中，我们探讨了JAK2 V617F突变，或共存血栓性和止血危险因素，导致这些并发症。我们检查了32例ET，并寻找致病jak2 v617f突变和癌细胞突变：因子V leiden，凝血酶原和mthfr。我们还评估了纤维蛋白原，因子VIII和XII，蛋白C，蛋白质S和血清半胱氨酸水平的血浆水平。在患者的血浆和血小板裂解物中评估尿激酶浓度。患者与没有JAK2突变的患者之间的血栓并发症的数量没有差异。然而，我们发现许多血栓性和止血危险因素可能导致患者血栓和血栓形成。 （Folia Histochemica et Cytobiologica 2011; Vol.49,2，PP。267-271）

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