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首页> 外文期刊>Folia histochemica et cytobiologica >Expression of glucocorticoid receptor and glucose transporter-1 during placental development in the diabetic rat
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Expression of glucocorticoid receptor and glucose transporter-1 during placental development in the diabetic rat

机译：糖尿病大鼠胎盘发育期间糖皮质激素受体和葡萄糖转运蛋白-1的表达

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In various tissues, glucocorticoids (GCs) are known to downregulate glucose transport systems; however, their effects on glucose transporters (GLUTs) in the placenta of a diabetic rat are unknown. Glucocorticoid hormone action within the cell is regulated by the glucocorticoid receptor (GR). Thus, this study was designed to investigate the relationship between GR and glucose transporter expression in the placenta of the diabetic rat. Our immunohistochemical results indicated that GR and glucose transporter protein 1 (GLUT 1) are expressed ubiquitously in the trophoblast and endothelial cells of the labyrinthine zone, where maternal fetal transport takes place in the rat placenta. Expression of GR in the junctional zone of the rat placenta was detected in giant cells, and in some spongiotrophoblast cells, but not in the glycogen cells. GLUT 1 was present, especially in glycogen cells during early pregnancy, and in the spongiotrophoblast cells of the junctional zone during late pregnancy. Amounts of GR and GLUT 1 protein were increased towards the end of gestation both in the control and the diabetic placenta. However, at days 17 and 19 of gestation, only the placental GR protein was significantly increased in the streptozotocin-induced diabetic rats compared to control rats. Diabetes led to a significant decrease in placental weight at gestation day 15. In contrast, at gestational days 17 and 21, the weights of the diabetic placenta were significantly increased as compared with the controls. Moreover, diabetes induced fetus intrauterine growth retardation at gestational days 13, 17 and 21. In conclusion, the localization pattern of GR and GLUT 1 proteins in the same cell types led us to believe that there might be a relationship between GR and GLUT 1 expressions at the cellular level. GLUT 1 does not play a pivotal role in diabetic pregnancies. However, placental growth abnormalities during diabetic pregnancy may be related to the amount of GR. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 2, pp. 325–334)
机译：在各种组织中，已知糖皮质激素（GCS）是下调葡萄糖运输系统;然而，它们对糖尿病大鼠胎盘的对葡萄糖转运蛋白（凝乳）的影响是未知的。细胞内的糖皮质激素激素作用由糖皮质激素受体（GR）调节。因此，该研究旨在探讨糖尿病大鼠胎盘中GR和葡萄糖转运蛋白表达的关系。我们的免疫组织化学结果表明GR和葡萄糖转运蛋白1（凝乳1）在迷宫区的滋养细胞和内皮细胞中表达，其中孕妇胎儿发生在大鼠胎盘中。在巨粒细胞中检测到大鼠胎盘的连接区的GR的表达，并在一些肾细胞中进行，但不在糖原细胞中。存在于妊娠期间的糖原细胞，特别是在妊娠晚期接线区的肾上腺素细胞中存在的凝甘油。在对照和糖尿病胎盘中朝向妊娠结束时，GR和Grut 1蛋白的量增加。然而，在妊娠的第17和19日和19日，与对照大鼠相比，在链脲佐菌素诱导的糖尿病大鼠中只有胎盘GR蛋白显着增加。糖尿病导致妊娠第15天的胎盘重量显着降低。相反，在妊娠期17和21时，与对照相比，糖尿病胎盘的重量显着增加。此外，糖尿病在妊娠期13,17和21日诱导胎儿宫内生长迟缓。总之，GR和Grut 1蛋白在同一细胞类型中的定位模式导致我们认为GR和GLUT 1表达之间可能存在关系在细胞水平。 Thut 1在糖尿病患者中没有发挥枢轴作用。然而，糖尿病患者期间的胎盘生长异常可能与GR的量有关。 （Folia Histochemica et Cytobiologica 2011; Vol.49,2，PP。325-334）

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