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首页> 外文期刊>Folia histochemica et cytobiologica >Expression of glucocorticoid receptor and glucose transporter-1 during placental development in the diabetic rat
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Expression of glucocorticoid receptor and glucose transporter-1 during placental development in the diabetic rat

机译：糖尿病大鼠胎盘发育过程中糖皮质激素受体和葡萄糖转运蛋白-1的表达

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In various tissues, glucocorticoids (GCs) are known to downregulate glucose transport systems; however, their effects on glucose transporters (GLUTs) in the placenta of a diabetic rat are unknown. Glucocorticoid hormone action within the cell is regulated by the glucocorticoid receptor (GR). Thus, this study was designed to investigate the relationship between GR and glucose transporter expression in the placenta of the diabetic rat. Our immunohistochemical results indicated that GR and glucose transporter protein 1 (GLUT 1) are expressed ubiquitously in the trophoblast and endothelial cells of the labyrinthine zone, where maternal fetal transport takes place in the rat placenta. Expression of GR in the junctional zone of the rat placenta was detected in giant cells, and in some spongiotrophoblast cells, but not in the glycogen cells. GLUT 1 was present, especially in glycogen cells during early pregnancy, and in the spongiotrophoblast cells of the junctional zone during late pregnancy. Amounts of GR and GLUT 1 protein were increased towards the end of gestation both in the control and the diabetic placenta. However, at days 17 and 19 of gestation, only the placental GR protein was significantly increased in the streptozotocin-induced diabetic rats compared to control rats. Diabetes led to a significant decrease in placental weight at gestation day 15. In contrast, at gestational days 17 and 21, the weights of the diabetic placenta were significantly increased as compared with the controls. Moreover, diabetes induced fetus intrauterine growth retardation at gestational days 13, 17 and 21. In conclusion, the localization pattern of GR and GLUT 1 proteins in the same cell types led us to believe that there might be a relationship between GR and GLUT 1 expressions at the cellular level. GLUT 1 does not play a pivotal role in diabetic pregnancies. However, placental growth abnormalities during diabetic pregnancy may be related to the amount of GR.
机译：在各种组织中，糖皮质激素（GCs）会下调葡萄糖转运系统。然而，它们对糖尿病大鼠胎盘中葡萄糖转运蛋白（GLUTs）的影响尚不清楚。细胞内糖皮质激素的作用受糖皮质激素受体（GR）调节。因此，本研究旨在研究糖尿病大鼠胎盘中GR与葡萄糖转运蛋白表达之间的关系。我们的免疫组织化学结果表明，GR和葡萄糖转运蛋白1（GLUT 1）在迷宫区域的滋养层和内皮细胞中普遍存在，而母胎在大鼠胎盘中发生。在巨细胞和某些海绵滋养细胞中检测到GR在大鼠胎盘连接区的表达，但在糖原细胞中未检测到。 GLUT 1存在于妊娠初期的糖原细胞中，特别是在孕晚期的糖原细胞中，在妊娠后期的接合区的海绵滋养细胞中也存在。在对照组和糖尿病胎盘中，妊娠期末GR和GLUT 1蛋白的含量均增加。但是，在妊娠的第17天和第19天，与对照大鼠相比，链脲佐菌素诱导的糖尿病大鼠中仅胎盘GR蛋白显着增加。糖尿病在妊娠第15天导致胎盘重量显着下降。相比之下，在妊娠第17和21天，与对照组相比，糖尿病胎盘的重量显着增加。此外，糖尿病在妊娠第13、17和21天引起胎儿宫内发育迟缓。总而言之，在相同细胞类型中GR和GLUT 1蛋白的定位模式使我们相信GR和GLUT 1表达之间可能存在某种关系。在蜂窝级别。 GLUT 1在糖尿病妊娠中不发挥关键作用。但是，糖尿病妊娠期间胎盘生长异常可能与GR的量有关。

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