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首页> 外文期刊>Food Science & Nutrition >Preventive effects of combinative natural foods produced?by elite crop varieties rich in anticancer effects on N ‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats
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Preventive effects of combinative natural foods produced?by elite crop varieties rich in anticancer effects on N ‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats

机译：产生的组合天然食品的预防效应？通过抗癌抗体作物的精英作物品种对大鼠N-腈二乙胺诱导的大鼠肝细胞癌

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The World Cancer Research Fund International has released 32 anticancer effects (ACEs) that targeted every stage of cancer processes. Thus, we designed two formulas of natural food combination Diet I and Diet II, mainly produced by elite crop varieties rich in ACEs with different mixture ratios, and evaluated their cancer preventive effects on N‐ nitrosodiethylamine (NDEA)‐induced hepatocarcinogenesis. After 20?weeks of dietary intervention, Diet I and Diet II reduced incidence, size, and number of hepatic nodules ( p? ? 0.01) and prevented hepatic tumor formation in NDEA‐induced hepatocarcinogenesis rats. Low‐grade hepatic dysplasia incidence was 20% for Diet II and 40% for Diet I, and apparent hepatocellular carcinomas (HCC) rates were both 0, while 90% HCC in control diet treatment group ( p? ? 0.01). Diet I and Diet II ameliorated abnormal liver function enzymes, reduced serum alpha fetal protein, tumor‐specific growth factor, dickkopf‐related protein 1, tumor necrosis factor‐alpha and interleukin‐6 levels, regulated hepatic phase I and II xenobiotic‐metabolizing enzymes, enhanced antioxidant capacity, suppressed NDEA‐initiated oxidative DNA damage, and induced apoptosis coupled to down‐regulation of proinflammatory, invasion, and angiogenesis markers. Daily intake of combination diet produced from ACEs‐rich elite crop varieties can effectively prevent or delay occurrence and development of NDEA‐induced hepatocarcinogenesis in rats.
机译：世界癌症研究基金国际发布了32项抗癌效应（ACE），其针对癌症过程的每个阶段。因此，我们设计了两种天然食品组合饮食和饮食II的公式，主要由精英作物品种产生富含不同混合物比率的癌症，并评估其对N-硝基乙基氨基（NDEA）的癌症预防作用 - 诱导的肝癌发生。 20岁以下的膳食干预后，饮食和饮食II降低发病率，尺寸和肝结节数（P？<0.01），并在NDEA诱导的肝癌发生大鼠中预防肝肿瘤形成。饮食II的低级肝脏发育性发育率为20％，饮食I 40％，表观肝细胞癌（HCC）速率均为0，而90％HCC控制饮食治疗组（P？<？0.01）。饮食I和饮食II改善异常肝功能酶，减少血清α胎儿蛋白，肿瘤特异性生长因子，Dickkopf相关蛋白1，肿瘤坏死因子 - α和白细胞介素-6水平，调节肝相I和II异种素代谢酶，增强的抗氧化能力，抑制NDEA引发的氧化DNA损伤，并诱导凋亡，凋亡凋亡，促进促炎，侵袭和血管生成标志物。每日摄入来自富含ACES的精英作物品种产生的组合饮食可以有效预防或延缓大鼠NDEA诱导的肝癌发生的发生和发展。

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