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首页> 外文期刊>Food Science & Nutrition >Germinated brown rice combined with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis inhibits colorectal carcinogenesis in rats
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Germinated brown rice combined with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis inhibits colorectal carcinogenesis in rats

机译：发芽的糙米结合乳杆菌和双歧杆菌胚子。乳酸乳裂抑制大鼠结肠直肠癌

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Colorectal cancer is a common cancer strongly associated with diet. Certain probiotics and prebiotics possess an inhibitory activity against colorectal cancer, while synbiotics may be more effective in preventing this cancer than either prebiotics or probiotics alone. Germinated brown rice (GBR) is considered as a candidate prebiotics with anticancer potential. However, the effect of GBR combined with probiotics on colorectal cancer is not clear. The present study investigated the preventive effect of combination of GBR and Lactobacillus acidophilus , Bifidobacterium animalis subsp . lactis , or both on colorectal carcinogenesis and the possible mechanism in rats treated with 1,2‐dimethylhydrazine (DMH) and dextran sulfate sodium (DSS). DMH/DSS treatment induced preneoplastic aberrant crypt foci (ACF) and mucin‐depleted foci (MDF), reduced superoxide dismutase (SOD) activity, increased anti‐apoptotic Bcl‐2 expression, and decreased the expression of pro‐apoptotic p53, Bax, and caspase‐3 in the colon. Germinated brown rice alone or combined with probiotics inhibited the formation of MDF in the middle colon, enhanced the colonic expression of p53 and Bax, and increased the ratio of Bax/Bcl‐2. Combined treatment of GBR and probiotics inhibited the formation of ACF‐producing sialomucin (SIM‐ACF) and recovered the activity of SOD in the colon. Combination of GBR and L.?acidophilus further increased caspase‐3 expression and decreased Bcl‐2 expression. These findings suggest that GBR combined with L.?acidophilus and/or B.?animalis subsp . lactis may inhibit colorectal carcinogenesis by enhancing antioxidative capacity and inducing apoptosis. This synbiotics may be a potential functional food or chemopreventive agent for controlling colorectal cancer.
机译：结直肠癌是与饮食密切相关的常见癌症。某些益生菌和益生元具有针对结肠直肠癌的抑制活性，而同步可能更有效地预防这种癌症而不是单独使用益生元或益生菌。发芽的糙米（GBR）被认为是患有抗癌潜力的候选益生元。然而，GBR与益生菌联合结直肠癌的影响尚不清楚。本研究调查了GBR和乳杆菌，双歧杆菌患者的组合的预防效果。乳酸，或两者均在结肠直肠癌和用1,2-二甲基肼（DMH）和葡聚糖硫酸钠（DSS）处理的大鼠中的可能机制。 DMH / DSS治疗诱导促塑料异常隐窝灶（ACF）和粘蛋白耗尽的焦点（MDF），降低超氧化物歧化酶（SOD）活性，增加抗凋亡Bcl-2表达，并降低了促凋亡P53，Bax的表达，和冒号中的Caspase-3。单独使用的糙米或与益生菌合并抑制MDF在中间结肠中的形成，增强了P53和Bax的结肠表达，增加了Bax / Bcl-2的比例。 GBR和益生菌的组合治疗抑制了产生ACF产生的唾液酸（SIM-ACF）并回收结肠中的SOD活性。 GBR和L.?Acidophilus的组合进一步增加了Caspase-3表达和降低的Bcl-2表达。这些发现表明GBR与L.?Acidophilus和/或B.? animalis亚数据一起联合。乳酸可通过增强抗氧化能力和诱导细胞凋亡来抑制结肠直肠癌。该同步可以是用于控制结直肠癌的潜在功能性食品或化学预防剂。

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