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首页> 外文期刊>Frontiers in Neuroanatomy >Subplate Neurons as an Organizer of Mammalian Neocortical Development
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Subplate Neurons as an Organizer of Mammalian Neocortical Development

机译：亚壳神经元作为哺乳动物新奇发育的组织者

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Subplate neurons (SpNs) are one of the earliest born and matured neurons in the developing cerebral cortex and play an important role in the early development of the neocortex. It has been known that SpNs have an essential role in thalamocortical axon (TCA) pathfinding and the establishment of the first neural circuit from the thalamus towards cortical layer IV. In addition to this function, it has recently been revealed in mouse corticogenesis that SpNs play an important role in the regulation of radial neuronal migration during the mid-embryonic stage. Moreover, accumulating studies throw light on the possible roles of SpNs in adult brain functions and also their involvement in psychiatric or other neurological disorders. As SpNs are unique to mammals, they may have contributed to the evolution of the mammalian neocortex by efficiently organizing cortical formation during the limited embryonic period of corticogenesis. By increasing our knowledge of the functions of SpNs, we will clarify how SpNs act as an organizer of mammalian neocortical formation.
机译：亚壳神经元（SPN）是在开发的脑皮层中最早出生和成熟的神经元之一，并在Neocortex的早期发展中发挥着重要作用。已知SPN具有在ThalamoCortical Axon（TCA）路径（TCA）路径（TCA）路径（TCA）的基本作用以及从丘脑朝向皮质层IV的第一神经回路的建立。除此功能外，最近在小鼠皮质发生中揭示了SPN在中胚期径向神经元迁移的调节中发挥着重要作用。此外，累积研究对Spns在成人脑功能中的可能作用以及它们参与精神病或其他神经系统障碍的可能作用。当SPNs对哺乳动物是独一无二的，它们可能通过在皮质发生的有限胚胎周期期间有效地组织皮质形成来促进哺乳动物Neocortex的演变。通过增加我们对SPN的功能的知识，我们将澄清SPNS如何充当哺乳动物新奇地区的组织者。

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