• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in Immunology >The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases
【24h】

The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases

机译：免疫系统是雌激素作用的天然靶标：雌激素在两个原型自身免疫疾病中的反对作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Analogous to other physiological systems, the immune system also demonstrates remarkable sex differences. Although the reasons for sex differences in immune responses are not precisely understood, it potentially involves differences in sex hormones (estrogens, androgens, and differential sex hormone receptor-mediated events), X-chromosomes, microbiome, epigenetics among others. Overall, females tend to have more responsive and robust immune system compared to their male counterparts. It is therefore not surprising that females respond more aggressively to self-antigens and are more susceptible to autoimmune diseases. Female hormone (estrogen or 17β-estradiol) can potentially act on all cellular subsets of the immune system through estrogen receptor-dependent and -independent mechanisms. This minireview highlights differential expression of estrogen receptors on immune cells, major estrogen-mediated signaling pathways, and their effect on immune cells. Since estrogen has varied effects in female-predominant autoimmune diseases such as multiple sclerosis and systemic lupus erythematosus, we will mechanistically postulate the potential differential role of estrogen in these chronic debilitating diseases.
机译：类似于其他生理系统，免疫系统也表现出显着的性别差异。虽然没有精确理解免疫应答性差异的原因，但它可能涉及性激素（雌激素，雌激素和差异性激素受体介导的事件），X-染色体，微生物组，外观遗传学等差异。总体而言，与男性同行相比，女性往往具有更敏感和鲁棒的免疫系统。因此，女性对自我抗原更积极地反应并更容易受到自身免疫疾病的令人惊讶。雌激素（雌激素或17β-雌二醇）可以通过雌激素受体依赖性和依赖性机制来对免疫系统的所有细胞亚组作用。该临麦型突显了雌激素受体对免疫细胞，主要雌激素介导的信号传导途径的差异表达及其对免疫细胞的影响。由于雌激素在女性母中性自身免疫疾病中具有多种效应，例如多发性硬化和全身性红斑狼疮，我们将机械地假设雌激素在这些慢性衰弱疾病中的潜在差异作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号