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首页> 外文期刊>Gastroenterology research and practice >Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease Patients
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Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease Patients

机译：患者报告的结果（PRO-2）与溃疡性结肠炎和克罗恩病患者的内窥镜和组织学特征的相关性

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Background and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients’ reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency subscore and rectal bleeding. Endoscopic activity was determined using the Mayo scoring system for ulcerative colitis and the Simple Endoscopic Score for Crohn’s disease. Histopathological activity was assessed using a validated numeric scoring system. Results. We included 159 patients (63 Crohn’s disease with colonic involvement and 96 with ulcerative colitis). We found significant correlation between the Mayo endoscopic subscoring system and histology activity in ulcerative colitis, while no correlation was found in patients with Crohn’s disease. Patient-reported outcome showed inverse correlation with endoscopic and histological activity in Crohn’s disease (rs=?0.67; rs=?0.72), while positive correlation was found in ulcerative colitis (rs=0.84; rs=0.75). Interpretation and Conclusions. Patient-reported outcome is a practical and noninvasive tool for assessment of disease activity in ulcerative colitis patients but not in Crohn’s disease.
机译：背景和目标。炎症性肠病活动的测定决定了进一步的治疗方法和随访。我们的研究目的是研究患者报告的症状与内镜和组织学疾病活动之间的相关性。方法。在连续新诊断的新诊断患有第三节护理转诊中心的炎性肠病患者中进行了横截面研究。初始评估包括患者报告的大便频率群和直肠出血的结果。利用芥菜型结肠炎和克罗恩病的简单内窥镜评分测定内镜活性。使用经验证的数字评分系统评估组织病理学活性。结果。我们包括159名患者（63名克罗恩病，结肠受累和96例，溃疡性结肠炎）。我们发现溃疡性结肠炎中的Mayo内窥镜子检查系统和组织学活动之间的显着相关性，而克罗恩病的患者没有发现相关性。患者报告的结果表明克罗恩病中的内窥镜和组织学活性的反比异性（Rs = 0.67; rs = 0.72），而在溃疡性结肠炎中发现阳性相关性（Rs = 0.84;卢比= 0.75）。解释和结论。患者报告的结果是用于评估溃疡性结肠炎患者疾病活动但不在克罗恩病中的实用而非侵入性的工具。

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