...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Functional Foods In Health And Disease >Neuroprotective and immune effects of active forms of vitamin D3 and docosahexaenoic acid in Alzheimer disease patients
【24h】

Neuroprotective and immune effects of active forms of vitamin D3 and docosahexaenoic acid in Alzheimer disease patients

机译：阿尔茨海默病患者维生素D3活性形式的神经保护和免疫效应

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neurodegenerative diseases, in particular Alzheimer disease (AD), afflict an increasing proportion of the older population with aging. Decreased exposure to sunlight and decreased consumption of fish, fruits, and vegetables, are two epidemiological factors that appear to be related to the pandemic of AD. In addition to replacing simple with complex carbohydrates and avoiding saturated fat, two nutritional components, vitamin D (acting through the endogenous hormonal form 1α,25 dihydroxyvitamin D, 1,25D) and docosahexaenoic acid (DHA) (acting through the docosanoid lipidic modulators resolvins and neuroprotectins) have high potential for prevention of Alzheimer disease. 1,25D is a neuroprotective, it acts both directly and indirectly in neurons by improving the clearance of amyloid-beta by macrophages/microglia. Resolvins and neuroprotectins inhibit amyloidogenic processing of amyloid-precursor protein, inflammatory cytokines, and apoptosis. It is likely that the increased consumption of vitamin D and fish oil could prevent neurodegeneration in some subjects by maintaining adequate endocrine, paracrine, and/or autocrine production of 1,25D and the DHA-derived lipidic modulators. Before firm recommendations of the dosage can be proposed, however, the in vivo effects of vitamin D3 and DHA supplementation should be investigated by prospective studies.
机译：神经退行性疾病，特别是阿尔茨海默病（AD），折磨着较老龄化的较高人群的比例。减少了暴露于阳光和鱼，水果和蔬菜的消耗减少，是两个流行病学因素，似乎与广告大流行有关。除了用复杂的碳水化合物替代简单，避免饱和脂肪，两种营养成分，维生素D（通过内源性激素形式1α，25二羟基素D，1,25d）和十二碳六烯酸（DHA）（通过二甘油脂脂质调节剂的溶解素作用并且神经保护菌素具有高潜力的预防阿尔茨海默病。 1,25d是一种神经保护，它通过通过提高巨噬细胞/微胶质细胞的淀粉样蛋白β的间隙直接和间接地在神经元中起作用。腐败素和神经保护菌素抑制淀粉样蛋白前体蛋白，炎性细胞因子和细胞凋亡的淀粉样蛋白加工。通过维持足够的内分泌，旁分泌和/或自分泌产量为1,25d和DHA衍生的脂肪酸调节剂，维生素D和鱼油的消耗量增加可能会导致一些受试者的神经变性。然而，在熟悉剂量建议之前，可以提出维生素D3和DHA补充的体内效应，通过前瞻性研究调查。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号