• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Medicine. >Intoxication with 3-MeO-PCP alone: A case report and literature review
【24h】

Intoxication with 3-MeO-PCP alone: A case report and literature review

机译：单独用3-Meo-PCP中毒：案例报告和文献综述

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rationale: 3-Methoxyphencyclidine ( 3-MeO-PCP ) is a new psychoactive substance derived from phencyclidine. Although it can lead to severe intoxications, the main manifestations and optimal management have not been well characterized. Here, we report 2 cases of 3-MeO-PCP intoxication in the same patient, and summarize the manifestations of this intoxication reported in literature. Patient concerns: A 17-year-old male purchased a bag of 3-MeO-PCP on the Internet but took an oral dose (200 mg) that corresponds to the less active isomer 4-MeO-PCP. He developed high blood pressure (158/131 mm Hg), tachycardia (100 bpm), and neurological manifestations (confusion, hypertonia, nystagmus, and then agitation). A maculopapular rash appeared, although this may have been related to the administration of midazolam. Hyperlactatemia (2.6 mmol/L) was the main laboratory finding. Seven days later, he returned to the emergency department after sniffing 50 mg of 3-MeO-PCP . High blood pressure, tachycardia, and neurological manifestations (psychomotor impairment and dysarthria) were present but less severe than after the first intoxication. Diagnosis: In the first intoxication, the blood and urine 3-MeO-PCP concentrations were, respectively, 71.1 ng/mL and 706.9 ng/mL. Conventional toxicity tests were all negative. In the second intoxication, biological samples were not available. Interventions: In the first intoxication, treatment consisted of intravenous hydration and midazolam. The patient was transferred to an intensive care unit for monitoring. After the second intoxication, he was monitored for 12 hours. Outcomes: The patient's condition improved quickly in both cases. Lessons: These cases provide additional information on the manifestations of 3-MeO-PCP intoxication. These manifestations are mainly cardiovascular (high blood pressure, tachycardia) and neurological. The fact that second (50 mg) intoxication was less severe than the first (200 mg) is suggestive of a dose–effect relationship for 3-MeO-PCP . The first case also emphasizes the risk of dosing errors caused by the similarity between the names “ 3-MeO-PCP ” and “4-MeO-PCP.”.
机译：理由：3-甲氧基苯（3-Meo-PCP）是一种从Phenyclidine衍生的新的精神活性物质。虽然它可能导致严重的毒害，但主要表现和最佳管理并没有很好地表征。在这里，我们在同一患者中报告了2例3-Meo-PCP中毒，并总结了文学中报告的这种中毒的表现。患者担忧：一名17岁的男性在互联网上购买了一袋3-Meo-PCP，但患有口服剂量（200mg），对应于较低的活性异构体4-Meo-PCP。他开发出高血压（158/131 mm Hg），心动过速（100bpm）和神经系统表现（混乱，高渗，眼球震颤，然后搅动）。出现了马穗瓣皮疹，尽管这可能与咪达唑仑的给药有关。超障碍血症（2.6mmol / L）是主要的实验室发现。七天后，他在嗅到50毫克3-Meo-PCP后回到了急诊部门。高血压，心动过速和神经系统表现（精神接种障碍和讨厌）存在，但比第一次中毒后不太严重。诊断：在第一中毒，血液和尿3-MeO-PCP浓度分别为71.1ng / ml和706.9ng / ml。常规毒性测试都是阴性的。在第二种中毒中，无法使用生物样品。干预：在第一中毒中，治疗包括静脉水合和咪达唑仑。患者转移到密集监护单元进行监测。在第二中毒后，他被监测了12个小时。结果：两种情况下患者的病症迅速提高。课程：这些案例提供了有关3-Meo-PCP中毒的表现的额外信息。这些表现形式主要是心血管（高血压，心动过速）和神经系统。第二种（50mg）中毒的事实小于第一（200mg）的严重严重是针对3-Meo-PCP的剂量效应关系的提示。第一种案例还强调了由名称“3-Meo-PCP”和“4-Meo-PCP”之间的相似性引起的给药错误的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号