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Moxibustion therapy for treating patients with primary osteoporosis: A systematic review and meta-analysis protocol

机译：艾灸治疗原发性骨质疏松症患者：系统审查和元分析方案

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Background: Primary osteoporosis (POP) is a common disease among elderly, which increase the risk of fracture and impact to the quality of life. As a Chinese traditional therapy, moxibustion has been commonly applied in treating chronic musculoskeletal diseases in China. Many trails have shown that moxibustion therapy is effective in treating primary osteoporosis . The protocol aims to present the methods used to access the effectiveness and safety of moxibustion therapy for patients with primary osteoporosis . Methods: The following databases will be searched from their inception: the Cochrane Central Register of Controlled Trails(CENTRAL), Pubmed, EMBASE, China National Knowledge Infrastructure(CNKI), Chinese Biomedical Literature Database(CBM), Chinese Scientific Journal Database (VIP database), and Wan-Fang Database. Clinical randomized controlled trials related to moxibustion therapy for treating primary osteoporosis will be included, regardless of publication status and languages. Study selection, data collection, and quality assessment will be independently conducted by 2 researchers. We will select the fixed-effects or random-effects model according to the heterogeneity assessment for data synthesis. Bone mineral density(BMD) will be the primary outcomes. Visual analogue scale(VAS), response rate, TCM Syndrome scale(TCMSS), bone gla protein(BGP), alkaline phosphatase(BALP), blood calcium(Ca), blood phosphate(P), quality of life(QOL) will be the second outcomes. If it is appropriate for meta-analysis, RevMan V.5.3 statistical software will be used. Otherwise, a systematic narrative synthesis will be conducted. The results will be presented as risk ratio (RR) with 95% confidence intervals (CIs) for dichotomous data and weight mean difference(WMD) or standard mean difference (SMD) 95% CIs for continuous data.
机译：背景：主要骨质疏松症（POP）是老年人的常见疾病，这增加了骨折和对生活质量的影响。作为中国传统治疗，艾灸通常适用于治疗中国慢性肌肉骨骼疾病。许多踪迹表明，艾灸治疗在治疗原发性骨质疏松症方面是有效的。该协议旨在介绍用于获得艾灸治疗的患者对初级骨质疏松症患者的有效性和安全性的方法。方法：将从他们的成立中搜索以下数据库：Cochrane中央登记册（中央），PubMed，Embase，中国国家知识基础设施（CNKI），中国生物医学文献数据库（CBM），中国科学期刊数据库（VIP数据库）和万芳数据库。无论出版状态和语言如何，都将包括与艾灸治疗治疗原发性骨质疏松症的临床随机对照试验。学习选择，数据收集和质量评估将由2名研究人员独立进行。我们将根据数据合成的异质性评估选择固定效果或随机效应模型。骨矿物密度（BMD）将是主要结果。视觉模拟量表（VAS），响应速率，中医综合征秤（TCMS），骨果糖蛋白（BGP），碱性磷酸酶（BALP），血钙（CA），血磷（P），生活质量（QOL）将是第二个结果。如果适用于Meta-Analysis，Revman V.5.3将使用统计软件。否则，将进行系统的叙事合成。结果将作为风险比（RR）呈现95％置信区间（CIS），用于二分数据和重量平均差（WMD）或标准平均差（SMD）95％CIS，用于连续数据。

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