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首页> 外文期刊>Medicine. >Clevidipine use after first-line treatment failure for perioperative hypertension in neurosurgical patients: A single-center experience
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Clevidipine use after first-line treatment failure for perioperative hypertension in neurosurgical patients: A single-center experience

机译：围手术诊高血压在神经外科患者围手术期后的Clevidipine使用：单中心经验

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Perioperative hypertension is a common occurrence in the neurosurgical population, where 60% to 90% of the patients require treatment for blood pressure (BP) control. Nicardipine and clevidipine have been commonly used in neurocritical settings. This retrospective, observational study assessed the effectivity of the administration of clevidipine after nicardipine treatment failure in neurosurgical patients. We retrospectively reviewed the medical charts of adult patients who were admitted to our neurosurgical department and received clevidipine after nicardipine treatment failure for the control of BP. The primary effectivity outcome was the comparison of the percentage of time spent at targeted SBP goals during nicardipine and clevidipine administration, respectively. A total of 12 adult patients treated with clevidipine after nicardipine treatment failure and were included for data analysis. The median number of events that required dose-titration was 20.5 vs 17 during the administration of nicardipine and clevidipine , respectively ( P = .534). The median percentage of time spent at targeted SBP goal was 76.2% during the administration of nicardipine and 93.4% during the administration of clevidipine ( P = .123). Our study suggests that clevidipine could be an alternative effective drug with an acceptable benefit/risk ratio in the neurosurgical population that fails to achieve BP control with nicardipine treatment.
机译：围手术期高血压是神经外科人群的常见发生，其中60％至90％的患者需要治疗血压（BP）控制。 Nicardipine和Clevidipine通常用于神秘环境。这种回顾性的观察性研究评估了神经外科患者尼卡丁治疗失败后Clevidipine施用的效果。我们回顾性地审查了成年患者的医学图表，该患者被录取为我们的神经外科部门，并在Nicardipine治疗失败治疗BP后接受Clevidipine。主要效果结果是在Nicardipine和Clevidipine施用期间在靶向SBP目标下花费的时间百分比的比较。 Nicardipine治疗失败后，共有12名成年患者治疗Clevidipine，并包括用于数据分析。在施用Nicardipine和Clevidipine期间，所需剂量滴定的中值的事件数为20.5Vs17（p = .534）。在尼卡丁的施用期间，在目标SBP目标下花费的时间的中位数为76.2％，施用Clevidipine期间93.4％（P = .123）。我们的研究表明，Clevidipine可以是一种替代有效药物，在神经外科人群中具有可接受的益处/风险比，该药物未能通过Nicardipine治疗实现BP对照。

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