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首页> 外文期刊>Medicine. >Serial anti-tuberculous immune responses during the follow-up of patients with tuberculous pleurisy
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Serial anti-tuberculous immune responses during the follow-up of patients with tuberculous pleurisy

机译：在结核性胸膜炎患者的随访期间连续抗结核免疫反应

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Little is known about the decay kinetics of interferon (IFN)-γ response and its influencing factors in tuberculous pleurisy . We enrolled thirty-two patients with tuberculous pleurisy prospectively and followed up at month 0, 6, and 9, at which time peripheral venous blood was drawn for interferon gamma release assay (IGRA) by means of QuantiFERON-TB Gold In-Tube (QFT-GIT). Demographic and clinical data were captured. To identify significant predictive factors influencing the IFN-γ response, multiple linear regression analyses were performed. Percentage of CD4+, CD8+, Vγ2Vδ2 T cells and Treg cells were measured by flow cytometry. The percentage of QFT-GIT-positive patients at baseline, month 6 and month 9 were 96.9% (30/32), 90.6% (29/32) and 84.4% (27/32), respectively. Quantitative IFN-γ response at baseline were significantly correlated with symptom duration ( P = .003, R 2 = 0.261) and age ( P = .041, R 2 = 0.132). Besides, the decreases of the IFN-γ response at month 6 and month 9 were positively correlated with the IFN-γ level at baseline. The dynamic tendency of the percentages of Treg cells was similar to the IFN-γ responses at each time-point. Quantitative IFN-γ response could be influenced by host immune status, instead of disease burden and anti- tuberculosis treatment. IGRA is probably not a useful biomarker of treatment efficacy in tuberculous pleurisy .
机译：关于干扰素（IFN）-γ反应的衰变动力学及其在结核性胸膜炎中的影响因素几乎令人着重。我们注册了前瞻性的三十二个患有结核性胸膜性的患者，并在第0,6和9名中随访，目的是通过Quantiferon-Tb金中的温干扰素γ释放测定法（IGRA）吸取周围静脉血液（QFT -git）。捕获人口统计和临床数据。为了确定影响IFN-γ响应的显着预测因素，进行了多元线性回归分析。通过流式细胞术测量CD4 +，CD8 +，Vγ2VΔ2T和Treg细胞的百分比。基线，6个月和第9款的QFT-Git阳性患者的百分比分别为96.9％（30/32），90.6％（29/32）和84.4％（27/32）。基线的定量IFN-γ响应与症状持续时间显着相关（p = .003，r 2 = 0.261）和年龄（p = .041，r 2 = 0.132）。此外，在第6个月和第9月9日的IFN-γ响应的降低与基线IFN-γ水平正相关。 Treg细胞百分比的动态趋势与每个时间点的IFN-γ响应类似。定量IFN-γ反应可能受到宿主免疫状态的影响，而不是疾病负担和抗结核治疗。 IGRA可能不是结核性胸膜炎治疗效果的有用生物标志物。

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