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Statins reduce new-onset atrial fibrillation after acute myocardial infarction: A nationwide study

机译：急性心肌梗死后，他汀类药物减少了新的心房颤动：全国范围内的研究

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Atrial fibrillation (AF) is an important complication of acute myocardial infarction (AMI). The association between AF and serum lipid profile is unclear and statin use for lowering the incidence of new-onset AF remains controversial. The objective of this study was to investigate whether statins confer a beneficial effect on AF after AMI. Data available in the Taiwan National Health Insurance Research Database on 32886 AMI patients between 2008 and 2011 were retrospectively analyzed. Total 27553 (83.8%) had complete 1-yr follow-up data. Cardiovascular outcomes were analyzed based on the baseline characteristics and AF type (existing, new-onset, or non-AF). AF groups had significantly higher incidence of heart failure (HF), stroke, all-cause death, and major adverse cardiac and cerebrovascular event (MACCE) after index AMI (all P .05). In contrast, myocardial re-infarction (re-MI) was not significantly different among the three groups ( P = .95). Statin use tended to be associated with lower risk of new-onset AF after AMI (HR: 0.935; 95% confidence interval (CI): 0.877–0.998; P = .0427). Existing AF and new-onset AF subgroups had similar cardiovascular outcomes after AMI and were both inferior to the non-AF group. Statin tended to reduce new-onset AF after AMI.
机译：心房颤动（AF）是急性心肌梗死（AMI）的重要并发症。 AF和血清脂质曲线之间的关联尚不清楚，并且他汀类药物用于降低新发起AF的发生率仍然存在争议。本研究的目的是研究他汀类药物是否会对AMI之后对AF有益效果。回顾性分析了2008年至2011年间的32886年AMI患者的台湾国家健康保险研究数据库。总计27553（83.8％）已完成1年后续数据。基于基线特征和AF类型（现有，新的展开或非AF）分析心血管结果。在指数AMI（所有P <0.05）之后，AF组的心力衰竭（HF），中风，全因死亡和主要不良心囊和脑血管事件（MACCE）的发病率显着更高。相比之下，三组（P = 0.95）中的心肌再梗塞（RE-MI）没有显着差异。他汀类药物使用往往与AMI之后的新opset AF的风险较低（HR：0.935; 95％置信区间（CI）：0.877-0.998; p = .0427）。现有的AF和New-Onset AF亚组在AMI之后具有类似的心血管结果，并且既不差到非AF组。他汀类药物倾向于减少AMI后的新手AF。

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