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Efficacy of salbutamol in the treatment of infants with bronchiolitis: A meta-analysis of 13 studies

机译：Salbutamol在服用支气管炎婴幼儿的疗效：13项研究的Meta分析

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Background: To systematically evaluate the clinical efficacy of salbutamol treatment in infants with bronchiolitis . Methods: A systematic review and meta-analysis of randomized controlled trials (RCTs) investigating the use of salbutamol in infants with bronchiolitis was performed. The Cochrane Risk of Bias Assessment Tool was used to evaluate the quality of RCTs. Data were extracted and meta-analyzed using STATA version 12.0 (StataCorp, College Station, TX). Results: Thirteen RCTs, including a total of 977 participants, were assessed in the present meta-analysis. Results indicated that salbutamol therapy for bronchiolitis in infants led to an increase in respiratory rate (weighted mean difference [WMD] 2.26 [95% confidence interval {CI} 0.36–4.16]) and higher heart rate (WMD 12.15 [95% CI 9.24–15.07]). However, as a selective β 2 -agonist, salbutamol did not improve the clinical severity score of infants with bronchiolitis (WMD –0.11 [95% CI –0.26 to 0.03]), length of hospital stay (WMD 0.12 [95% CI –0.32 to 0.56]), or oxygen saturation (WMD 0.20 [95% CI –0.35 to 0.75]). Conclusion: Based on the results of this systematic review, the use of salbutamol had no effect on bronchiolitis in children 24 months of age. Moreover, the treatment can also lead to side effects, such as high heart rate. As such, salbutamol should not be recommended for treatment of bronchiolitis in infants .
机译：背景：为了系统地评估婴儿患有支气管炎婴儿的临床疗效。方法：进行随机对照试验（RCT）的系统评价和荟萃分析，调查使用支气管炎的婴儿使用沙丁胺醇。 BIAS评估工具的Cochrane风险用于评估RCT的质量。使用STATA 12.0版（Statacorp，College Station，TX）提取数据和Meta分析。结果：在目前的荟萃分析中评估了11个RCT，包括总共977名参与者。结果表明，婴儿支气管炎的沙丁胺醇治疗导致呼吸速率的增加（加权平均差异[WMD] 2.26 [95％置信区间{CI} 0.36-4.16]）和较高的心率（WMD 12.15 [95％CI 9.24- 15.07]）。然而，作为一种选择性β2-一方，Salbutamol并未改善婴儿的婴儿（WMD -0.11 [95％CI -0.26至0.03]）的临床严重程度，住院时间（WMD 0.12 [95％CI-0.32]至0.56]）或氧饱和度（WMD 0.20 [95％CI-0.35至0.75]）。结论：根据该系统审查的结果，使用Salbutamol对儿童的Bronchiolita is The Bronchiolity的使用没有影响。此外，治疗也可以导致副作用，例如高心率。因此，不应建议沙丁胺醇用于治疗婴儿的支气管炎。

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