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Association of rs2230806 in ABCA1 with coronary artery disease: An updated meta-analysis based on 43 research studies

机译：RS2230806在ABCA1与冠状动脉疾病的关联：基于43研究研究的更新荟萃分析

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Background: As a key gene in the reverse transport pathway of cholesterol, ABCA1 (ATP-binding cassette transporter A1) plays an important role in the pathogenesis of coronary artery disease ( CAD ). In the ABCA1 , rs2230806 is the most widely studied polymorphism and its role has been controversial. Methods: We performed an updated meta-analysis by searching online electronic databases using the PubMed, Web of Science, Embase, Cochrane Library, EMBASE, Google Scholar, China National Knowledge Infrastructure, and Wan Fang databases before June 28, 2019. STATA12.0 software was used to perform a series of analyses on the data, including genetic effect model, heterogeneity, sensitivity, and publication bias analysis. Results: Based on our inclusion and exclusion criteria, finally 43 articles including a total of 34,348 subjects (14,085 CAD cases and 20,263 healthy controls) were investigated. Results showed that carrying the K allele in rs223086 in the overall population significantly reduced the risk of CAD (OR = 0.745, 95% CI = 0.687–0.809, P .001). After the ethnicity stratification analysis, the above phenomenon was found to be significant in Asian populations (OR = 0.686, 95% CI = 0.633–0.744, P .001), marginally significant in Caucasians (OR = 0.887, 95% CI = 0.786–1.001, P = .051), and not significant in other populations (OR = 0.851, 95% CI = 0.558–1.297, P = .452). Further stratified according to the sample size in the Asian and Caucasian populations, in the Asian the K allele is more protective in small samples than large samples; however, in the Caucasian small samples carrying the K allele play a protective role while large samples are negative. In addition, according to the source of the control population and the geographical location in China, the results showed that rs2230806 was significantly associated with CAD in any group. Five genetic models (allelic, recessive, dominant, homozygote, and heterozygote) were analyzed in the above analysis. Conclusion: The K allele of rs2230806 was significantly associated with decreased risk of CAD , especially in Asian populations and small sample Caucasians.
机译：背景：作为胆固醇逆转途径中的关键基因，ABCA1（ATP结合盒式磁带转运蛋白A1）在冠状动脉疾病（CAD）的发病机制中起重要作用。在ABCA1中，RS2230806是最广泛研究的多态性，其作用具有争议。方法：通过使用Pubmed，Embase，Cochrane图书馆，Embase，Google Scholar，中国国家知识基础设施和WAN Fang Databuss搜索在线电子数据库进行了更新的META分析，2019年6月28日之前。Stata12.0软件用于对数据进行一系列分析，包括遗传效果模型，异质性，灵敏度和出版物偏见分析。结果：根据我们的纳入和排斥标准，最后调查了43篇，其中共有34,348名受试者（14,085例和20,263例健康对照）。结果表明，在整体人群中携带k等位基因在RS223086中显着降低了CAD的风险（或= 0.745,95％CI = 0.687-0.809，P <.001）。在种族分层分析之后，发现上述现象在亚洲群体中具有重要意义（或= 0.686,95％CI = 0.633-0.744，P <.001），在高加索人中略微显着（或= 0.887,95％CI = 0.786 -1.001，p = .051），在其他群体中不显着（或= 0.851,95％ci = 0.558-1.297，p = .452）。根据亚洲和高加索人群中的样品大小进一步分层，在亚洲的亚洲k等位基因比大型样品更加保护，而不是大型样品;然而，在携带K等位基因的高加索小样品中，在大型样品阴性的同时发挥保护作用。此外，根据控制人口的来源和中国的地理位置，结果表明，RS2230806在任何组中与CAD显着相关。在上述分析中分析了五种遗传模型（等位基因，隐性，占主导地位，纯合子和杂合子）。结论：CAD的风险降低，RS2230806的K等位基因显着相关，特别是在亚洲人口和小样本中的高加索人。

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