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首页> 外文期刊>Microbiology >Oxidative stress and disruption of labile iron generate specific auxotrophic requirements in Salmonella enterica
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Oxidative stress and disruption of labile iron generate specific auxotrophic requirements in Salmonella enterica

机译：氧化胁迫和稳定性的破坏在沙门氏菌中产生特异性营养性要求

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The response of a cell to integrated stresses was investigated using environmental and/or genetic perturbations that disrupted labile iron homeostasis and increased oxidative stress. The effects of the perturbations were monitored as nutritional requirements, and were traced to specific enzymic targets. A yggX gshA cyaY mutant strain required exogenous thiamine and methionine for growth. The thiamine requirement, which had previously been linked to the Fe–S cluster proteins ThiH and ThiC, was responsive to oxidative stress and was not directly affected by manipulation of the iron pool. The methionine requirement was associated with the activity of sulfite reductase, an enzyme that appeared responsive to disruption of labile iron homeostasis. The results are incorporated in a model to suggest how the activity of iron-containing enzymes not directly sensitive to oxygen can be decreased by oxidation of the labile iron pool.
机译：使用扰动稳定性稳态和氧化应激增加的环境和/或遗传扰动来研究细胞对综合应力的响应。扰动的影响被监测为营养要求，并追溯到特定的酶靶标。 A YGGX GSHA人体突变株需要外源硫胺素和蛋氨酸的生长。先前已与Fe-S簇蛋白ThIH和Thic相关的硫胺素要求对氧化应激并不直接受铁池的操纵影响。甲硫氨酸的要求与亚硫酸盐还原酶的活性有关，一种酶响应于不稳定的熨平稳定性的破坏。结果掺入模型中以表明如何通过氧化稳定性铁池的氧化来降低如何对氧气直接敏感的含铁酶的活性。

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