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首页> 外文期刊>Microorganisms >Manipulation of Alcohol and Short-Chain Fatty Acids in the Metabolome of Commensal and Virulent Klebsiella pneumoniae by Linolenic Acid
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Manipulation of Alcohol and Short-Chain Fatty Acids in the Metabolome of Commensal and Virulent Klebsiella pneumoniae by Linolenic Acid

机译：用亚烯酸的共生和毒性Klebsiella肺炎代谢中的酒精和短链脂肪酸的操纵

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Endogenous alcohol produced by the gut microbiome is transported via the bloodstream to the liver for detoxification. Gut dysbiosis can result in chronic excess alcohol production that contributes to the development of hepatic steatosis. The aim of this study was to examine whether linolenic acid can manipulate the production of harmful alcohol and beneficial short-chain fatty acids (SCFAs) in the metabolome of commensal Klebsiella pneumoniae ( K. pneumoniae ) and the virulent K. pneumoniae K1 serotype. Glucose fermentation by the K. pneumoniae K1 serotype yielded increased production of alcohol and decreased SCFAs (especially acetate and propionate) compared to those of commensal K. pneumoniae . However, the use of linolenic acid instead of glucose significantly reduced alcohol and increased SCFAs in the fermentation media of the K. pneumoniae K1 serotype. The work highlights the value of shaping the microbial metabolome using linolenic acid, which can potentially regulate the gut–liver axis for the prevention and treatment of alcohol-induced liver diseases.
机译：通过肠道微生物组产生的内源性醇通过血液向肝脏输送以进行排毒。肠道脱泻症可导致慢性过量的酒精生产，这有助于肝脏脂肪变性的发展。本研究的目的是检查亚麻酸是否可以在共同的Klebsiella肺炎（K.Pnnuumoniae）和毒力K.Pneumoniae K1血清型中制备有害酒精和有益短链脂肪酸（SCFA）的产生。 K.Pneumoniae K1血清型的葡萄糖发酵产生与共生K.肺炎相比，醇的产量增加并降低了SCFA（尤其是乙酸盐和丙酸盐）。然而，使用亚麻酸代替葡萄糖显着降低了K.Pneumoniae K1血清型的发酵培养基中的醇和增加的SCFA。该工作突出了使用亚麻酸形成微生物代谢物的价值，这可能会调节肠肝轴用于预防和治疗酒精诱导的肝脏疾病。

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