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首页> 外文期刊>European Journal of Translational Myology >Chemotherapy-induced muscle wasting: association with NF-κB and cancer cachexia
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Chemotherapy-induced muscle wasting: association with NF-κB and cancer cachexia

机译：化疗诱导的肌肉浪费：与NF-κB和癌症恶化的关联

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A compounding feature of greater than 50% of all cancers is the high incidence of the cachexia syndrome, a complex metabolic disorder characterized by extreme weight loss due mainly to the gross depletion of skeletal muscle tissue. Although studies into the cause of cancer cachexia has spanned over multiple decades, little is known about the effects of various cancer treatments themselves on cachexia. For example, chemotherapy agents induce side effects such as nausea and anorexia, but these symptoms do not fully account for the changes seen with cancer cachexia. In this study we examine the effects of chemotherapeutic compounds, specifically, cisplatin in the colon-26 adenocarcinoma model of cancer cachexia. We find that although cisplatin is able to reduce tumor burden as expected, muscle wasting in mice nevertheless persists. Strikingly, cisplatin alone was seen to regulate muscle atrophy, which was independent of the commonly implicated ubiquitin proteasome system. Finally, we show that cisplatin is able to induce NF-κB activity in both mouse muscles and myotube cultures, suggesting that an additional side effect of cancer treatment is the regulation of muscle wasting that may be mediated through activation of the NF-κB signaling pathway.
机译：大于50％的癌症的复合特征是毒思综合征的高发病率，一种复杂的代谢紊乱，其特征在于极端体重减轻，主要是骨骼肌组织的总枯竭。虽然研究了癌症恶魔群岛的原因，但在多十年内跨越，甚至闻名于各种癌症治疗本身对恶病因的影响。例如，化疗剂诱导副作用如恶心和厌食症，但这些症状没有完全占癌症恶病症的变化。在这项研究中，我们研究了化学治疗化合物的作用，特别是顺铂在癌症恶病症的结肠-26腺癌模型中。我们发现，尽管顺铂能够随着预期的预期减少肿瘤负担，但小鼠的肌肉浪费仍然存在。令人惊讶的是，单独的顺铂被视为调节肌肉萎缩，其与常用的泛素蛋白酶体系统无关。最后，我们表明，顺铂能够在小鼠肌肉和肌室培养中诱导NF-κB活性，这表明癌症治疗的额外副作用是可以通过激活NF-κB信号通路的激活来调节肌肉浪费。

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