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首页> 外文期刊>Nigerian Journal of Physiological Sciences >Neuronal function in male Sprague Dawley rats during normal ageing
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Neuronal function in male Sprague Dawley rats during normal ageing

机译：正常老化期间雄性Sprague Dawley大鼠神经元功能

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During normal ageing, there are physiological changes especially in high energy demanding tissues including the brain and skeletal muscles. Ageing may disrupt homeostasis and allow tissue vulnerability to disease. To establish an appropriate animal model which is readily available and will be useful to test therapeutic? strategies during normal ageing, we applied behavioral approaches to study age-related changes in memory and motor function as a basis for neuronal function in ageing in male Sprague Dawley rats. 3 months, n=5; 6 months, n=5 and 18 months, n=5 male Sprague Dawley Rats were tested using the Novel Object Recognition Task (NORT) and the Elevated plus Maze (EPM) Test. Data was analyzed by ANOVA and the Newman-Keuls post hoc test. The results showed an age-related gradual decline in exploratory behavior and locomotor activity with increasing age in 3 months, 6 months and 18 months old rats, although the values were not statistically significant, but grooming activity significantly increased with increasing age, p0.05. Importantly, we established a novel finding that the minimum distance from the novel object was statistically significant between 3 months and 18 months old rats, (p0.05) and this may be an index for age-related memory impairment in the NORT. Altogether, we conclude that the male Sprague Dawley rat show age-related changes in neuronal function and may be a useful model for carrying out investigations into the mechanisms involved in normal ageing.
机译：在正常衰老期间，存在生理变化，特别是在高能量要求组织中，包括脑和骨骼肌。衰老可能会破坏稳态并允许组织脆弱性对疾病。建立一个易于获得的适当的动物模型，可用于测试治疗方法？正常衰老策略，我们应用行为方法研究记忆和电机功能的年龄相关变化作为雄性Sprague Dawley大鼠老龄化的神经元功能的基础。 3个月，n = 5; 6个月，n = 5和18个月，使用新的对象识别任务（NORT）和升高的Plus Maze（EPM）测试测试N = 5只雄性Sprague Dawley大鼠。数据通过ANOVA和Newman-Keuls进行分析。结果表明，随着年龄的增长3个月，6个月和18个月大鼠的年龄越来越大的探索性行为和运动活性的年龄相关的逐步下降，尽管价值没有统计学意义，但随着年龄的增加，散装活动显着增加，P <0.05 。重要的是，我们建立了一种小说发现，新型物体的最小距离在3个月和18个月之间的大鼠统计学意义（P <0.05），这可能是NORT中的年龄相关的记忆障碍指数。总之，我们得出结论，雄性Sprague Dawley大鼠表现出与神经元功能的年龄相关的变化，并且可以是进行对正常老化作用机制的研究的有用模型。

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