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首页> 外文期刊>Nigerian Journal of Physiological Sciences >Effect of low dose Lead (Pb) administration on tail immersion test and formalin-induced pain in wistar rats: Possible modulatory role of cobalt (II) chloride
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Effect of low dose Lead (Pb) administration on tail immersion test and formalin-induced pain in wistar rats: Possible modulatory role of cobalt (II) chloride

机译：低剂量铅（Pb）给药对Wistar大鼠尾浸渍试验和福尔马林诱导的疼痛的影响：氯化钴（II）的可能调节作用

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Lead (Pb) is cheap and there is a long tradition of its use, but its toxic effects have also been recognized. There is increased public health concern regarding the hazards of low dose Pb exposure to adults and children. Studies have shown the risks for hypertension, decrements in renal function, subtle decline in cognitive function, and adverse reproductive outcome at low blood Pb level. In this study, the possible modulatory role of cobalt (II) chloride (CoCl2) on low level Pb exposure on tail immersion test and formalin induced pain was investigated. Twenty adult Wistar rats of both sexes (weight 150g to 200g) were used. The animals were divided into four groups (n = 5) and administered Pb (5mg/kg), Pb (5mg/kg) + CoCl2 (50mg/kg) and CoCl2 (50mg/kg) orally for twenty-eight days. The last group served as control and were given distilled water only. In the tail immersion test, there was no significant change in reaction time for all three groups when compared to the control. In the formalin-induced pain, pain score after five and forty-five minutes also do not show significant change for all the three groups when compared to control. This work suggested that exposure to 5mg/kg Pb for twenty-eight days do not significantly impair reaction time in tail immersion test and pain score in formalin induced pain in Wistar rats. Also, administration of 50mg/kg CoCl2 do not improve performance of the animals in the experiments.
机译：铅（PB）便宜，使用悠久的传统，但其毒性效应也得到了认可。有关对成人和儿童的低剂量Pb暴露的危害有增加的公共卫生问题。研究表明，高血压的风险，肾功能下降，认知功能的微妙下降，以及低血PB水平的不良生殖结果。在该研究中，研究了氯化钴（COCl2）对尾浸渍试验和福尔马林诱导疼痛的低水平PB暴露的可能调节作用。使用二十种成年人的Wistar大鼠（重量150g至200g）。将动物分成四组（n = 5）并施用Pb（5mg / kg），Pb（5mg / kg）+ Cocl2（50mg / kg）和Cocl2（50mg / kg）28天。最后一组作为对照，仅给予蒸馏水。在尾浸渍试验中，与对照相比，所有三组的反应时间没有显着变化。在福尔马林诱导的疼痛中，五个和四十五分钟后的疼痛评分也没有显示所有三组的重大变化与控制相比。这项工作表明，暴露于5mg / kg Pb 28天的暴露于福尔胺诱导的Wistar大鼠牙型疼痛中的尾浸渍试验和疼痛评分中的反应时间不会显着损害反应时间。此外，50mg / kg COCl2的给药不会改善实验中的动物的性能。

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