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首页> 外文期刊>Nigerian Journal of Physiological Sciences >Haemostatic indices as markers for monitoring pulmonary tuberculosis treatment
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Haemostatic indices as markers for monitoring pulmonary tuberculosis treatment

机译：血压指数作为监测肺结核治疗的标志物

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Tuberculosis (TB) is an infectious disease inducing a state of chronic inflammation which could affect the haemostatic mechanism as part of host defences against infection. Proper diagnosis and monitoring of tuberculosis patients undergoing therapy is still a challenge especially in a poor resource country such as Nigeria. This study aims to assess some haemostatic indices of tuberculosis patients and their possible use as markers in monitoring response to anti-tuberculosis treatment. One hundred and twenty TB patients aged 15-60 years and 120 apparently healthy (control) subjects age and gender-matched were studied. Demographic/bio data was compiled by interview and from patients’ case notes. Diagnosis of TB was by sputum smear microscopy, radiography and clinical assessment. Platelet count (PLT), platelet factor 4 (PF4), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin clotting time (TCT) and fibrinogen (FIB) were determined using standard techniques. The platelet factor 4, prothrombin time, activated partial thromboplastin time and fibrinogen levels of TB patients were significantly higher while the thrombin clotting time was significantly lower (P0.05) when compared with healthy subjects. While PF4, TCT and FIB improved significantly (P0.05) as anti-tuberculosis therapy progressed, PLT, PT and APTT remained the same. It is concluded that abnormal activation of haemostasis occurs in TB condition thus pre-disposing TB patients to bleeding complications. Furthermore, platelet factor 4, thrombin clotting time and fibrinogen improved as therapy progressed and therefore may be used as markers for monitoring response to anti-tuberculosis therapy.
机译：结核病（TB）是一种感染性疾病，诱导慢性炎症状态，这可能影响止血机制，作为针对感染的宿主防御的一部分。接受治疗的结核病患者的适当诊断和监测仍然是一个挑战，特别是在尼日利亚等贫困资源国家。本研究旨在评估结核病患者的一些止血索引及其可能使用作为对抗结核病治疗的反应的标记。研究了一百二十六年患者15-60岁及120例显然健康（对照）受试者年龄和性别匹配。人口统计/生物数据是通过面试和患者的案件票据编制的。通过痰涂片显微镜，射线照相和临床评估诊断。使用标准技术确定血小板计数（PLT），血小板因子4（PF4），凝血酶原时间（Pt），激活的部分血栓形成时间（APTT），凝血酶凝结时间（TCT）和纤维蛋白原（FIB）。与健康受试者相比，TB患者的血小板因子4，凝血酶原时间，活化的部分血浆时间和纤维蛋白原水平显着更高，而凝血酶凝血凝血凝血凝血凝固时间显着降低（P <0.05）。虽然PF4，TCT和FIB显着改善（P <0.05）作为抗结核治疗进展，PLT，PT和APTT保持不变。结论是，在Tb条件下发生血肿异常的激活，从而预先将Tb患者进行渗出并发症。此外，血小板因子4，凝血酶凝结时间和纤维蛋白原改善的疗法进展，因此可以用作用于监测对抗结核疗法的反应的标志物。

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