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首页> 外文期刊>Nigerian Journal of Physiological Sciences >A study of pain threshold, interleukins and NLR in diabetic polyneuropathy in a selected Nigerian population
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A study of pain threshold, interleukins and NLR in diabetic polyneuropathy in a selected Nigerian population

机译：尼日利亚人群中糖尿病多发病患者疼痛阈值，白细胞介素和NLR的研究

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Pain serves a protective function and is often lost in chronic conditions such as painful diabetic neuropathy (PDN). This has been reported to be associated with ongoing inflammation. This study aims to investigate an association between body immune responses, neutrophil-lymphocyte ratio (NLR) and pain perception in DPN patients. Sixty volunteers were recruited for the study. 30 control and 30 diagnosed DPN patients (used Biothesiometer). All subjects were trained and informed consents were obtained. The pain threshold was significantly (p0.05) lower in DPN (23.48±1.19 sec) compared to control group (30.38±1.9 sec), there was significant lower NLR in DPN (1.27±0.09) compared to control group (1.93±0.1) and the serum level of IL6 (15.31±0.85 pg/ml) in DPN was significantly higher compared to control group (11.9±0.15 pg/ml), likewise the serum level of IL10 (13.26±2.78 pg/ml) in DPN is significantly higher compared to control group (6.59±1.07 pg/ml). This study showed that hyperalgesia seen in patients with DPN was independent of increased NLR, and increased IL6 & IL10 seen in this group of patients indicates need to further explore the role of immunological response in the pathogenesis and progression of DPN.
机译：疼痛是一种保护功能，并且通常在慢性条件下丢失，例如痛苦的糖尿病神经病变（PDN）。据报道，这与正在进行的炎症有关。本研究旨在探讨身体免疫应答，中性粒细胞淋巴细胞比（NLR）和DPN患者疼痛感知之间的关联。招募了六十名志愿者进行研究。 30对照和30名诊断的DPN患者（二手Biothesiometer）。所有受试者均获得培训并获得通知同意。与对照组（30.38±1.9秒）相比，DPN（23.48±1.19秒）下降（P <0.05），与对照组（1.27±0.09）相比，DPN（1.27±0.09）的显着低的NLR（1.93±0.1 ）与对照组（11.9±0.15pg / ml）相比，DPN中的IL6（15.31±0.85pg / ml）的血清IL6（15.31±0.85pg / ml）显着更高，同样是DPN中的IL10（13.26±2.78pg / ml）的血清水平与对照组相比显着更高（6.59±1.07 pg / ml）。本研究表明，DPN患者中看到的痛觉患者与NLR的增加无关，并且在该组患者中看到的IL6＆IL10增加表明需要进一步探讨免疫应答在DPN发病机制和进展中的作用。

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