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首页> 外文期刊>Nigerian Journal of Physiological Sciences >Coconut water prevents renal and hepatic changes in offspring of monosodium glutamate-treated Wistar rat dams
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Coconut water prevents renal and hepatic changes in offspring of monosodium glutamate-treated Wistar rat dams

机译：椰子水可预防谷氨酸钠处理的Wistar大鼠后代后代的肾和肝脏变化

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Monosodium glutamate (MSG) is a widely-consumed taste enhancer which has been implicated in the aetiology of renal and hepatic dysfunction in adults and their offspring. There is increasing evidence on the therapeutic properties of Coconut Water (CW) in kidney and liver disorders. This study investigated the effects of CW on renal and hepatic functions in offspring of MSG-fed dams. Twelve female Wistar rats (120 – 140 g) were grouped into four as follows; Control (10 ml/Kg distilled water), MSG (0.08 mg/Kg), CW (10 ml/Kg) and MSG+CW. Treatments were given orally daily commencing two weeks prior to mating, throughout mating and gestation until parturition. All dams received standard rodent diet and drinking water ad libitum throughout the study. After weaning on Post-Natal Day (PND) 28, serum was obtained from offspring for assay of liver and renal function. Histological analysis of the livers and kidneys were performed on both dams and offspring. There was no significant difference in liver enzymes, urea, creatinine and albumin levels amongst the offspring on PND 28. However, liver and kidney sections from MSG dams and their offspring showed early degenerative changes which were not evident in renal and hepatic tissues from CW and MSG+CW dams and offspring. These observations suggest that coconut water protects against monosodium glutamate-induced renal and hepatic dysfunction in dams and offspring.
机译：谷氨酸钠（MSG）是一种广泛消耗的味道增强剂，其涉及成人肾病和肝功能障碍的疾病及其后代。肾脏和肝障碍椰子水（CW）治疗性质的越来越多的证据。本研究调查了CW对MSG馈电水坝后代肾和肝功能的影响。如下，将12只女性Wistar大鼠（120-140g）分成四种;对照（10ml / kg蒸馏水），msg（0.08mg / kg），cw（10ml / kg）和msg + cw。在交配前两周内开始治疗治疗，在整个交配和妊娠期直至分娩。所有水坝都在全研究中收到了标准的啮齿动物饮食和饮用水广告。在原始日（PND）28后断奶后，从后代获得血清，用于肝脏和肾功能的检测。在坝和后代进行肝脏和肾脏的组织学分析。在PND 28中的后代肝酶，尿素，肌酐和白蛋白水平没有显着差异。然而，来自MSG水坝的肝脏和肾脏切片及其后代表现出早期退行性变化，从CW和CW和肝脏组织中没有明显明显MSG + CW水坝和后代。这些观察结果表明椰子水防止谷氨酸含量诱导的肾脏和后代肾脏和肝功能障碍。

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