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The coordination of nuclear envelope assembly and chromosome segregation in metazoans

机译：核包封组装与美唑烷染色体隔离的协调

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The nuclear envelope (NE) is composed of two lipid bilayer membranes that enclose the eukaryotic genome. In interphase, the NE is perforated by thousands of nuclear pore complexes (NPCs), which allow transport in and out of the nucleus. During mitosis in metazoans, the NE is broken down and then reassembled in a manner that enables proper chromosome segregation and the formation of a single nucleus in each daughter cell. Defects in coordinating NE reformation and chromosome segregation can cause aberrant nuclear architecture. This includes the formation of micronuclei, which can trigger a catastrophic mutational process commonly observed in cancers called chromothripsis. Here, we discuss the current understanding of the coordination of NE reformation with chromosome segregation during mitotic exit in metazoans. We review differing models in the field and highlight recent work suggesting that normal NE reformation and chromosome segregation are physically linked through the timing of mitotic spindle disassembly.
机译：核封（NE）由两个脂质双层膜组成，该膜包围真核基因组。在相互间，NE由数千个核孔隙络合物（NPC）穿孔，允许进出细胞核。在美唑烷中的有丝分裂期间，NE被分解，然后以能够在每个子细胞中形成适当的染色体隔离和形成单个核的方式重新组装。协调网元改造和染色体隔离中的缺陷会导致异常的核建筑。这包括微核的形成，其可以引发癌症常见的灾难突变过程，称为Chromothripsis。在这里，我们讨论了在美唑烷中有丝分裂出口期间用染色体隔离的NE改造的理解。我们审查了该领域的不同模型，并突出了最近的工作，表明正常的NE改造和染色体隔离在物理上通过有丝分裂主轴拆卸的时机物理连接。

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