...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nucleus >Are the processes of DNA replication and DNA repair reading a common structural chromatin unit?
【24h】

Are the processes of DNA replication and DNA repair reading a common structural chromatin unit?

机译：DNA复制和DNA修复的过程是读常见的结构染色质单位吗？

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Decades of investigation on genomic DNA have brought us deeper insights into its organization within the nucleus and its metabolic mechanisms. This was fueled by the parallel development of experimental techniques and has stimulated model building to simulate genome conformation in agreement with the experimental data. Here, we will discuss our recent discoveries on the chromatin units of DNA replication and DNA damage response. We will highlight their remarkable structural similarities and how both revealed themselves as clusters of nanofocal structures each on the hundred thousand base pair size range corresponding well with chromatin loop sizes. We propose that the function of these two global genomic processes is determined by the loop level organization of chromatin structure with structure dictating function.
机译：几十年的基因组DNA调查使我们在核心内的组织和代谢机制中提出了深入的见解。这是通过实验技术的平行发展来推动的，并刺激模型建筑以模拟与实验数据一致的基因组构象。在这里，我们将讨论我们最近关于DNA复制和DNA损伤反应的染色质单位的发现。我们将突出显示出显着的结构性相似性，以及如何将自己作为纳米焦结构的簇，每个簇结构每个在十万个碱基对尺寸范围内与染色质环尺寸相应良好。我们提出，这两个全局基因组过程的功能由染色质结构的环级组织与结构指示功能决定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号