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首页> 外文期刊>Nanomedicine research journal. >Ratio of Drug/carrier as Dominant Factor in Determining Size of Doxorubicin-Loaded Beta-1,3- Glucan Nanoparticles: An Artificial Neural Networks Study
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Ratio of Drug/carrier as Dominant Factor in Determining Size of Doxorubicin-Loaded Beta-1,3- Glucan Nanoparticles: An Artificial Neural Networks Study

机译：药物/载体的比例作为测定多柔比蛋白β-1,3-葡聚糖纳米粒子尺寸的主要因素：人工神经网络研究

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Size of nanoparticles is an important parameter in determining many of their properties. In this work, nanoparticles of β-1,3-glucan containing doxorubicin (Dox) in conjugated and unconjugated forms (Con-Dox-Glu and Un-Dox-Glu, respectively) were prepared. Then, artificial neural networks (ANNs) were used to find the effect of different formulation/processing parameters on their particle size, which was measured using dynamic light scattering (DLS). The parameters included ratio of Dox/Carrier as well as concentrations of polyethyleneimine (PEI), NaOH and succinic anhydride (Sa). To do so, fifty samples having different values of the four parameters were prepared and their particle size was measured. The data were divided randomly into training, test and unseen data. The ANN model demonstrated that in both conjugated and unconjugated forms, Dox/Carrier ratio is the dominant factor determining the particle size. Also, concentration of PEI showed to be important in determining particle size of unconjugated form of the nanoparticles. The remaining parameters indicated no considerable effect on the particle size.
机译：纳米粒子的大小是确定它们的许多性质的重要参数。在这项工作中，制备以共轭和未缀合的形式（分别的缀合物（Con-Dox-glu和Un-Dox-glu）的β-1,3-葡聚糖含有多柔比星（DOX）的纳米粒子。然后，使用人工神经网络（ANNS）来寻找不同配方/加工参数对其粒度的影响，其使用动态光散射（DLS）测量。参数包括DOx /载体的比例以及聚乙烯亚胺（PEI），NaOH和琥珀酸酐（SA）的浓度。为此，制备具有四个参数不同值的五十个样品，并测量它们的粒度。将数据随机划分为培训，测试和看不见的数据。 ANN模型证明，在共轭和未缀合形的形式中，DOX /载波比是确定粒度的主要因素。而且，PEI的浓度表明在确定纳米颗粒的未缀合形形式的粒径中表明是重要的。其余参数表明对粒度没有相当大的影响。

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