...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nanomedicine research journal. >Sub-chronic intraperitonealy toxicity assessments of modified silver nanoparticles capped coated Myrtus communis-derived the hydrolyzable tannins in a mice model
【24h】

Sub-chronic intraperitonealy toxicity assessments of modified silver nanoparticles capped coated Myrtus communis-derived the hydrolyzable tannins in a mice model

机译：修饰银纳米粒子的亚慢性腹膜内毒性评估覆盖染色的Myrtus Communis-衍生的小鼠模型中的可水解单宁

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective(s): The use of silver nanoparticles in the field of biomedicine is increasing day by day, but less attention has been paid to its toxicity. In this paper, the ability of the silver nanoparticles produced by a green synthesis procedure to protect the liver and its effects on liver function in male mice was investigated in a sub-chronic toxicity study. Methods: The silver nanoparticles functionalized the hydrolyzable tannin fraction of Myrtus communis (MC-AgNPs) were used for testing in vivo sub-chronic toxicity in mice model. The MC-AgNPs and Ag were intraperitoneally injected with different doses 5 times a week over 90 days. The biochemical, hematological factors were determined using an autoanalyzer following the routine procedures. In addition, histopathological test of liver tissue in laboratory mice were examined through haematoxylin & eosin staining. Results: The obtained results showed that liver enzymes (AST, ALT, and ALP) were decreased. The mean value ± standard deviation of white blood cells, lymphocytes, red blood cells and Hb were increased, while red blood cells and hemoglobin decreased. Histopathological investigations indicated no obvious effect on hepatic cyto-architecture in the group receiving silver nanoparticles (50 mg/kg), and mild inflammation in the port space. In the groups receiving silver nanoparticles (100 and 200 mg/kg), mild inflammation, and moderate inflammation were observed in the port space and pre portal, respectively. Conclusions: The findings indicated that AgNPs could be safe even for long-term use in a therapeutic period if hybridized with active biomolecules.
机译：目的：在生物医学领域中使用银纳米颗粒日益增长，但对其毒性的注意力不太关注。本文在亚慢性毒性研究中研究了绿色合成程序生产的银纳米粒子以保护肝脏保护肝脏的能力及其对雄性小鼠肝功能的影响。方法：官能化银纳米粒子官能化的水解规划（MC-AGNPS）的水解鞣量部分用于小鼠模型中的体内慢性毒性测试。 MC-AGNP和AG在90天内每周用不同剂量的剂量注射5次。使用常规程序后的自动分析仪测定生化，血液学因素。此外，通过氧毒素和曙红染色检查实验室小鼠肝组织的组织病理学试验。结果：得到的结果表明，肝酶（AST，ALT和ALP）降低。白细胞，淋巴细胞，红细胞和Hb的平均值±标准偏差增加，而红细胞和血红蛋白降低。组织病理学调查表明，对接受银纳米颗粒（50mg / kg）的基团中肝细胞结构没有明显影响，并且在港口空间中轻微炎症。在接受银纳米颗粒（100和200mg / kg）的基团中，分别观察到港口空间和前门户中的温和炎症和中度炎症。结论：调查结果表明，如果用活性生物分子杂交，即使在治疗期间长期使用，AgNP也可能是安全的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号