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首页> 外文期刊>Reproductive Biology and Endocrinology >Gonadotropin-releasing hormone agonist combined with hormone replacement therapy does not improve the reproductive outcomes of frozen-thawed embryo transfer cycle in elderly patients: a retrospective study
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Gonadotropin-releasing hormone agonist combined with hormone replacement therapy does not improve the reproductive outcomes of frozen-thawed embryo transfer cycle in elderly patients: a retrospective study

机译：促进促促丙素释放激素激动剂联合激素替代疗法并未改善老年患者中冻融胚胎转移循环的生殖结果：回顾性研究

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With the rapid development of whole embryo freezing technology, more and more frozen-thawed embryo transfer (FET) was used in assisted reproductive technology. However, the best FET program for elderly women has not been finalized. We intended to explore the reproductive outcomes of traditional hormone replacement treatment and a gonadotropin-releasing hormone agonist (GnRHa) combined with hormone replacement treatment in the frozen-thawed embryo transfer cycle of elderly patients. In this retrospective analysis, we analyzed 1264 elderly patients (aged 38?years or older) who underwent FET at three reproductive centers between 2015 and 2017. According to the endometrial preparation protocol, we divided the patients into a GnRHa combined with hormone replacement treatment (GnRHa-HRT) group and traditional hormone replacement treatment (HRT) group. The clinical pregnancy, ongoing pregnancy, live birth, and abortion rates were compared between groups. One-way analysis of variance of the two groups revealed no significant difference in the clinical (33.58% vs. 37.15%) and ongoing pregnancy rates (19.40% vs. 25.10%) between the GnRHa-HRT and HRT groups. The live birth rate (17.54% vs. 24.10% p?=?0.0229) of the GnRHa-HRT group was lower than that of the HRT group, whereas the abortion rate (45.56% vs. 32.97% p?=?0.0252) was higher than that of the HRT group. However, multivariate analysis showed no significant difference in the live birth rate (p?=?0.1333) or abortion rate (p?=?0.1881) between the GnRHa-HRT and HRT groups. The number of embryos transferred, level of the embryo, and age and ovarian reserve of the patient significantly affected final reproductive outcomes. A GnRH agonist combined with hormone replacement therapy did not improve the reproductive outcomes of frozen-thawed embryo cycles in elderly patients.
机译：随着全胚胎冷冻技术的快速发展，越来越多的冰冻解冻的胚胎转移（FET）用于辅助生殖技术。然而，老年妇女的最佳FET计划尚未完成。我们旨在探讨传统激素替代治疗的生殖结果和促性腺激素释放激素激动剂（GNRHA）联合在老年患者的冷冻解冻胚胎转移周期中的激素替代处理。在这一回顾性分析中，我们分析了1264名老年患者（38岁了38岁，年龄或以上），他们在2015年和2017年间在三个生殖中心接受了FET。根据子宫内膜制剂方案，我们将患者分为GNRHA与激素替代治疗相结合（ GNRHA-HRT）组和传统激素替代治疗（HRT）组。在群体之间比较临床怀孕，持续怀孕，生育和堕胎率。两组差异的单向分析显示出GNRHA-HRT和HRT组之间的临床（33.58％vs.17.15％）和正在进行的妊娠率（19.40％vs.25.10％）的显着差异。 Live出生率（17.54％对24.10％p？= 0.0229）的GnRHA-HRT组低于HRT组，而流产率（45.56％与32.97％p？= 0.0252）是高于HRT组。然而，多变量分析显示出在GNRHA-HRT和HRT基团之间的活生生率（P？= 0.1333）或流产率（P？= 0.1881）的显着差异。转移的胚胎数量，胚胎水平，患者的年龄和卵巢储备会显着影响最终的生殖结果。 GNRH激动剂联合激素替代疗法并未改善老年患者的冷冻解冻胚胎循环的生殖蛋白。

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