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首页> 外文期刊>Revista Cubana de Hematología, Inmunología y Hemoterapia >Procedencia y fenotipo del sistema Rh en donantes negativos en un Hemocentro colombiano
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Procedencia y fenotipo del sistema Rh en donantes negativos en un Hemocentro colombiano

机译：哥伦比亚血栓瓣负捐赠者RH系统的出差和表型

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Introduction: The Rh system is composed of more than 56 antigens capable of producing hemolytic disease, defined by serological methods; being the most important and therefore the largest antigens of the system, the antigens D, C, c, E and e. These antigens are located on two proteins that are expressed in the membrane of erythrocytes Rh D and RhCE. Objective: To determine the frequency of the C, c, E and e antigens of the Rh system in Rh negative blood donors of Hemocentro Centro Oriente Colombiano. Methods: A cross-sectional descriptive study that included 193 blood donors from the Hemocentro Centro Oriente Colombiano, phenotyping the antigens of the Rh system, using the gel card technique. The phenotypic frequency of the Rh antigen was calculated, in percentages and for the processing of the information, the statistical package SPSS version 21.0 was used in Spanish where all the analysis of the population data was performed. With inclusion criteria to be a voluntary blood donor and exclusion, be hemoclasified as DEL antigen, weak D and partial D. Results: The analyzed samples were obtained from the central tubulant of the fractionated unit of red blood cells, three phenotypes were identified with a frequency of :cde / cde95.86%, cde / cdE 3.10% and cde / Cde 1, 04%; it was evidenced that the participants come from diverse municipalities of the department of Boyac?? and other regions of the country like Eastern Plains, Santander and Cundinamarca. The Rh factor and the antigens of the Rh system are highly polymorphic at the population level, given the immunological importance of the antigens of the Rh system, which are directly related to the development of post transfusion hemolytic anemia and perinatal hemolytic disease, the extended phenotyping provides greater transfusional safety and follow-up to the status of the fetus or neonate.
机译：简介：RH系统由56多个能够产生溶血性疾病的抗原组成，由血清学方法定义;作为最重要的，因此是系统的最大抗原，抗原D，C，C，E和E。这些抗原位于两种蛋白质上，该蛋白质在红细胞RH d和Rhce的膜中表达。目的：确定Rh负血液供体RH系统的C，C，E和E抗原的频率，在Hemocentro Centro Oriente Colombiano中的Rh阴性献血者。方法：使用凝胶卡技术，包括来自Hemocentro Centro Oriente Oriente Colombiano的193个献血者的横截面描述性研究，从而用凝胶卡技术表现了RH系统的抗原。计算Rh抗原的表型频率，以百分比和处理信息的处理，统计包SPSS版本21.0用于西班牙语，其中执行了群体数据的所有分析。具有含有自愿血液供体和排斥的含有标准，被血液膨胀为Del抗原，弱D和部分D.结果：分析的样品从红细胞分级单元的中央管中获得，用A鉴定了三种表型频率：CDE / CDE95.86％，CDE / CDE 3.10％和CDE / CDE 1,04％;有人证明，参与者来自博伊克州的多元城？和国家的其他地区，如东部平原，桑坦德德和塞德南卡马卡。鉴于RH系统抗原的免疫学意义，RH系统的RH因子和RH系统的抗原在群体水平上具有直接相关的输血后溶血性贫血和围产期溶血性疾病，扩展表型术语为胎儿或新生儿的状态提供更大的转发安全性和后续行动。

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