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Probable Longer Incubation Period for Elderly COVID-19 Cases: Analysis of 180 Contact Tracing Data in Hubei Province, China

机译:老年人Covid-19案例可能更长的培养期:中国湖北省180例联系方式分析

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Background: Factors associated with the incubation period of COVID-19 are not fully known. The aim of this study was to estimate the incubation period of COVID-19 using epidemiological contact tracing data, and to explore whether there were different incubation periods among different age gr1oups. Methods: We collected contact tracing data in a municipality in Hubei province during the full outbreak period of COVID-19. The exposure periods were inferred from the history of travel in Wuhan and/or history of exposure to confirmed cases. The incubation periods were estimated using parametric accelerated failure time models accounting for interval censoring of exposures. Results: The incubation period of COVID-19 follows a Weibull distribution and has a median of 5.8 days with a bootstrap 95% CI: 5.4– 6.7 days. Of the symptomatic cases, 95% showed symptoms by 14.3 days (95% CI: 13.0– 15.7), and 99% showed symptoms by 18.7 days (95% CI: 16.7– 20.9). The incubation periods were not found significantly different between male and female. Elderly cases had significant longer incubation periods than young age cases (HR 1.49 with 95% CI: 1.09– 2.05). The median incubation period was estimated at 4.0 days (95% CI: 3.5– 4.4) for cases aged under 30, 5.8 days (95% CI: 5.6– 6.0) for cases aged between 30 and 59, and 7.7 days (95% CI: 6.9– 8.4) for cases aged greater than or equal to 60. Conclusion: The current practice of a 14-day quarantine period in many regions is reasonable for any age. Older people infected with SARS-CoV2 have longer incubation period than that of younger people. Thus, more attention should be paid to asymptomatic elderly people who had a history of exposure.
机译:背景:与Covid-19的潜伏期相关的因素不完全已知。本研究的目的是使用流行病学接触跟踪数据估算Covid-19的潜伏期,并探讨不同年龄GR1的不同孵化期。方法:在Covid-19的全面爆发期间,我们在湖北省的一家市中国的联系跟踪数据。从武汉旅行史上推断出暴露时期和/或暴露于确诊病例的历史。使用参数加速故障时间模型估计孵化期估计,占曝光的间隔审查。结果:Covid-19的潜伏期跟随威布尔分布,并具有5​​.8天的中位数,Bootstrap 95%CI:5.4-6.7天。在症状病例中,95%显示症状14.3天(95%CI:13.0-15.7),99%显示症状18.7天(95%CI:16.7-20.9)。孵育期没有显着差异在雄性和女性之间。年长案例比年轻年龄案例显着更长的潜伏期(HR 1.49,95%CI:1.09- 2.05)。估计在30%,5.8天(95%CI:5.6-6.0)下的4.0天(95%CI:3.5-4.4)估计为30天,5.8天,7.7天(95%CI) :6.9- 8.4)对于年龄大于或等于60的病例。结论:目前许多地区的14天检疫期的实践对于任何年龄都是合理的。感染SARS-COV2的老年人比较年轻人的孵化期更长。因此,应该更多地关注有暴露历史的无症状的老年人。

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