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首页> 外文期刊>Revista da Sociedade Brasileira de Medicina Tropical >Local and systemic effects caused by Crotalus durissus terrificus, Crotalus durissus collilineatus , and Crotalus durissus cascavella snake venoms in swiss mice
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Local and systemic effects caused by Crotalus durissus terrificus, Crotalus durissus collilineatus , and Crotalus durissus cascavella snake venoms in swiss mice

机译：克罗塔卢斯·德里累菌，克罗塔卢斯·德里累菌菌造成的地方和全身效应，以及瑞士小鼠的克罗塔卢斯·德里斯斯卡拉维拉蛇毒液

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INTRODUCTION: Crotalus envenomations cause serious complications and can be fatal without appropriate treatment. Venom isoforms present and inter/intraspecific variations in the venom composition can result in different symptoms presented by bites by snakes from the same species but from different geographical regions. We comparatively evaluated the local and systemic effects caused by Crotalus durissus terrificus ( Cdt ) , C.d. collilineatus ( Cdcolli ), and C.d. cascavella ( Cdcasc ) envenomation . METHODS: Venom chromatography was performed. Proteolytic, phospholipase, and LAAO activities were analyzed. Edema, myotoxicity, hepatotoxicity, nephrotoxicity, and coagulation alterations were evaluated. RESULTS: The venom SDS-PAGE analyses found the presence of convulxin, gyroxin, crotoxin, and crotamine in Cdt and Cdcolli venoms. Crotamine was not present in the Cdcasc venom. Cdt , Cdcollli , and Cdcasc venoms had no proteolytic activity. Only Cdcasc and Cdt venoms had phospholipase activity. LAAO activity was observed in Cdcolli and Cdcasc venoms. Cdcolli and Cdcasc venoms caused 36.7% and 13.3% edema increases, respectively. Cdt venom caused a 10% edema induction compared to those by other venoms. All venoms increased TOTAL-CK, MB-CK, and LDH levels (indicating muscle injury) and ALT, AST, GGT, and ALP levels (markers of liver damage) and were able to induce a neuromuscular blockade. Urea and creatinine levels were also altered in both plasma and urine, indicating kidney damage. Only Cdcolli and Cdcasc venoms increased TAPP and TAP. CONCLUSIONS: Together, these results allow us to draw a distinction between local and systemic effects caused by Crotalus subspecies, highlighting the clinical and biochemical effects produced by their respective venoms.
机译：介绍：克罗特展会造成严重并发症，并且没有适当的治疗，可能是致命的。存在的毒液同种型和毒液组合物的间/内差异可导致来自相同物种的蛇咬合呈现的不同症状，而是来自不同的地理区域。我们比较评价由Crotalus Durissus Treadus（CDT），C.D造成的局部和全身效应。 Collilineatus（CDColli）和C.D. Cascavella（Cdcasc）envenomation。方法：进行毒色谱法。分析蛋白水解，磷脂酶和Laao活动。评估水肿，肌毒性，肝毒性，肾毒性和凝血改变。结果：毒液SDS-PAGE分析发现CDT和Cdcolli毒液中的甘油蛋白，陀螺素，曲氧吡嗪和克罗那胺。 Cr酪胺不存在于Cdccasc毒液中。 CDT，Cdcollli和Cdcasc Venoms没有蛋白水解活性。只有CDCASC和CDT毒液有磷脂酶活性。在Cdcolli和Cdcasc Venoms中观察到Laao活性。 Cdcolli和Cdcasc Venoms造成36.7％和13.3％的水肿增加。 CDT毒液与其他毒液相比引起了10％的水肿诱导。所有毒液均增加总CK，MB-CK和LDH水平（表明肌肉损伤）和ALT，AST，GGT和ALP水平（肝脏损伤标记），并且能够诱导神经肌肉阻滞。尿素和肌酐水平也被改变在血浆和尿液中，表明肾脏损伤。只有Cdcolli和Cdcasc Venoms增加Tapp和Tap。结论：在一起，这些结果使我们能够在克罗塔卢斯亚种类造成的局部和全身效应之间区分，突出各自毒液产生的临床和生化效果。

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