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首页> 外文期刊>Open Journal of Urology >Mouthwash with Active Oxygen (blue&sup&®&/sup&m) Induces Keratinocytes Proliferation
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Mouthwash with Active Oxygen (blue&sup&®&/sup&m) Induces Keratinocytes Proliferation

机译：具有活性氧气（蓝色＆＆amp; reg;＆ / sup＆ m）淋湿

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Chlorhexidine is widely used in dentistry to treat various gingival conditions. Its side effects are widely described. Histologically, the gingiva consists of a stratified squamous epithelium, with a predominance of keratinocytes, the latter being fundamental in healing processes. Thus, the objective of this in vitro study was to evaluate the effects of a new product with active oxygen (blue~(®) m) on keratinocytes. Keratinocytes (HACAT) were incubated with different concentrations of blue ~( ® ) m (1, 10 and 100 μl/ml), and another well was used as a control, without the presence of mouthwash. After 24, 48 and 72 hours, cell proliferation was analyzed by CyQUANT ~( ® ) ) . It was possible to observe that lower concentrations (1 μl/ml) of blue ~( ® ) m increased cell proliferation in HACAT cell lines, while moderate and higher concentrations of mouthwash may present a cytotoxic effect. This is the first in vitro study with show ing that human keratinocytes cell line demonstrated greater proliferation rate when exposed to lower concentrations of blue ~( ® ) m mouthwash.
机译：氯己定广泛用于牙科治疗各种牙龈状况。其副作用被广泛描述。组织学上，牙龈由分层鳞状上皮组成，具有角质形成细胞的主要鳞状上皮，后者是愈合过程的基础。因此，在体外研究中的目的是评估新产品与活性氧气（蓝〜（＆＃174;）m）在角质形成细胞上的影响。用不同浓度的蓝色〜（＆＃174;）m（1,10和100μl/ ml）孵育角质形成细胞（HaCAT），并且使用另一个孔作为对照，而不会存在漱口水。 24,48和72小时后，通过Cyquant〜（＆＃174;）分析细胞增殖。可以观察到较低浓度（1μL/ ml）的蓝〜（＆＃174;）m增加了甘达细胞系中的细胞增殖，而中等和更高浓度的漱口水可能存在细胞毒性作用。这是第一个在体外研究，随着人角蛋白细胞细胞系在暴露于较低浓度的蓝色〜（＆＃174;）m漱口水中时，展示人角蛋白细胞细胞系呈现更大的增殖速率。

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