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首页> 外文期刊>Open Journal of Urology >Growth Hormone Releasing Hormone Receptors Antagonists and Cancers: Do GHRH-R Antagonists Play a Role in the Management of Prostate Cancer?
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Growth Hormone Releasing Hormone Receptors Antagonists and Cancers: Do GHRH-R Antagonists Play a Role in the Management of Prostate Cancer?

机译：生长激素释放激素受体拮抗剂和癌症：Dogrh-r拮抗剂在前列腺癌的管理中发挥作用吗？

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摘要

Growth hormone-releasing hormone (GHRH) and its receptors have been implicated in the progression of various tumors such as those of the prostate. Treatment modalities for prostate cancer in a localized stage or when it is still castration-sensitive yield good results in most patients. However, such treatments are only palliative in the advanced stage. Therefore, new therapeutic targets like growth hormone-releasing hormone receptor (GHRH-R) and its splice variants should be found in order to get effective treatments for more aggressive stages in prostate cancer. This review talks about the GHRH-R and its splice variants, the signaling pathways induced by GHRH to produce cancer, the structure activity relationship of GHRH-R antagonists and the resume of some in vitro and in vivo studies on the role of GHRH-R antagonists in the treatment of prostate cancer.
机译：生长激素释放激素（GHRH）及其受体涉及各种肿瘤的进展，例如前列腺的进展。治疗局部阶段前列腺癌的治疗方式或在大多数患者中仍然溶胀敏感的产量良好的结果。然而，这种治疗在高级阶段只是姑息性。因此，应发现新的生长激素释放激素受体（GHRH-R）等治疗靶标及其剪接变体，以获得有效治疗前列腺癌中的更具侵略性阶段。本综述谈到GhRH-R及其剪接变体，由GhRH引起的信号传导途径，以产生癌症，GhRH-R拮抗剂的结构活动关系和一些体外的简历以及体内研究GhRH-R的作用拮抗剂治疗前列腺癌。

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