The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

Goossens G.H.

首页> 外文期刊>Obesity facts : the European journal of obesity. >The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

【24h】

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

机译：肥胖症中的代谢表型：脂肪质量，体脂分布和脂肪组织功能

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The current obesity epidemic poses a major public health issue since obesity predisposes towards several chronic diseases. BMI and total adiposity are positively correlated with cardiometabolic disease risk at the population level. However, body fat distribution and an impaired adipose tissue function, rather than total fat mass, better predict insulin resistance and related complications at the individual level. Adipose tissue dysfunction is determined by an impaired adipose tissue expandability, adipocyte hypertrophy, altered lipid metabolism, and local inflammation. Recent human studies suggest that adipose tissue oxygenation may be a key factor herein. A subgroup of obese individuals - the ‘metabolically healthy obese' (MHO) - have a better adipose tissue function, less ectopic fat storage, and are more insulin sensitive than obese metabolically unhealthy persons, emphasizing the central role of adipose tissue function in metabolic health. However, controversy has surrounded the idea that metabolically healthy obesity may be considered really healthy since MHO individuals are at increased (cardio)metabolic disease risk and may have a lower quality of life than normal weight subjects due to other comorbidities. Detailed metabolic phenotyping of obese persons will be invaluable in understanding the pathophysiology of metabolic disturbances, and is needed to identify high-risk individuals or subgroups, thereby paving the way for optimization of prevention and treatment strategies to combat cardiometabolic diseases.

机译：由于肥胖令人慢性促进了几种慢性疾病，因此目前的肥胖疫情提出了一个主要的公共卫生问题。 BMI和总肥胖与人口水平的心肌疾病风险正相关。然而，体脂肪分布和脂肪组织功能受损，而不是总脂肪量，更好地预测各个水平的胰岛素抵抗和相关并发症。脂肪组织功能障碍取决于脂肪组织可扩张性，脂肪细胞肥大，改变的脂质代谢和局部炎症而确定。最近的人类研究表明脂肪组织氧合可以是本文的关键因素。肥胖个体的亚群 - “代谢健康的肥胖”（MHO） - 具有更好的脂肪组织功能，不太异位脂肪储存，并且比肥胖的代谢不健康人更胰岛素敏感，强调脂肪组织功能在代谢健康中的核心作用。然而，争议已经围绕着这种想法，即代谢性健康的肥胖可能被认为是非常健康的，因为MHO个体因其增加（有氧）代谢疾病风险，并且可能具有较低的寿命，而不是由于其他合并症而较低的寿命。肥胖人的详细代谢表型在理解代谢紊乱的病理生理学方面将是非常宝贵的，并且需要鉴定高风险的个体或亚组，从而铺平了用于对心脏素质疾病进行打击的预防和治疗策略的方式。

著录项

来源
《Obesity facts : the European journal of obesity.》 |2017年第3期|共9页
作者
Goossens G.H.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Depot- and obesity-related differences in adipogenesisAdipocyte hypertrophy and hyperplasia are known to facilitate lipid storage in adipose tissues by increasing adipocyte cell size and number, respectively. Adipogenesis is the process resulting in adipose tissue hyperplasia. Although depot-specific differences and obesity-related modulation of adipocyte size are well documented, available data on adipogenesis and adipose tissue hyperplasia are less conclusive. Most studies support a reduction of adipogenesis in the obese state. Preadipocytes of the subcutaneous fat depot appear to be more responsive to adipogenic stimulation compared with those from visceral fat compartments in most studies. A number of studies support the notion that adipose tissue expansion through hyperplasia reduces ectopic lipid excess and obesity-related complications. Several genetic variants have been identified in the genes coding for adipogenesis-regulating proteins. While some of these variants have been clearly associated with the phenotypes of obesity and obesity-related alterations, available data highlight the importance of considering gene–gene and gene–diet interactions. [J] . Julie. Lessard, André. Tchernof Clinical lipidology. . 2012,第5期

机译：脂肪形成与肥胖相关的差异已知脂肪细胞肥大和增生分别通过增加脂肪细胞的大小和数量来促进脂质在脂肪组织中的存储。脂肪形成是导致脂肪组织增生的过程。尽管已经有很多文献记载了贮库特异性差异和肥胖相关的脂肪细胞大小调节，但有关脂肪形成和脂肪组织增生的可用数据尚无定论。大多数研究支持在肥胖状态下减少脂肪形成。在大多数研究中，与来自内脏脂肪区室的脂肪细胞相比，皮下脂肪库的前脂肪细胞似乎对脂肪刺激更为敏感。许多研究支持这样的观点，即通过增生的脂肪组织扩张可以减少异位脂质过多和肥胖相关的并发症。在编码脂肪形成调节蛋白的基因中已经鉴定出几种遗传变异。尽管其中一些变异与肥胖症的表型和与肥胖有关的改变明显相关，但现有数据突出了考虑基因-基因和基因-饮食相互作用的重要性。
2. Association between fat mass, adipose tissue, fat fraction per adipose tissue, and metabolic risks: a cross-sectional study in normal, overweight, and obese adults [J] . Huebers Mark, Geisler Corinna, Bosy-Westphal Anja, European journal of clinical nutrition . 2019,第1期

机译：脂肪质量，脂肪组织，脂肪组织脂肪级分的关系，以及代谢风险：正常，超重和肥胖成年人的横截面研究
3. Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity. [J] . Smith SR, Lovejoy JC, Greenway F, Metabolism: Clinical and Experimental . 2001,第4期

机译：全身脂肪，腹部皮下脂肪组织区隔和内脏脂肪组织对肥胖的代谢并发症的贡献。
4. Serum levels of WISP1/CCN4 in subjects with type 2 diabetes: the relationships with body fat distribution and adipose tissue dysfunction [C] . V.V. Klimontov, D.M. Bulumbaeva, A.P. Lykov, International Multiconference Bioinformatics of Genome Regulation and StructureSystems Biology . 2018

机译：2型糖尿病患者的血清WISP1 / CCN4水平：与体脂分布和脂肪组织功能障碍的关系
5. Body Fat Determination of Stock-Type Horses in Varying Body Condition by Carcass Dissection, Rump Fat Thickness, and Deuterium Oxide Dilution and Fatty Acid Composition of Adipose Tissues. [D] . Ferjak, Emily Nicole. 2017

机译：通过Car体解剖，臀部脂肪厚度，氧化氘稀释和脂肪组织的脂肪酸含量测定不同身体状况下的种马的体脂。
6. The Metabolic Phenotype in Obesity: Fat Mass Body Fat Distribution and Adipose Tissue Function [O] . Gijs H. Goossens 2017

机译：肥胖者的代谢表型：脂肪量体内脂肪分布和脂肪组织功能
7. The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function [O] . Gijs H. Goossens 2017

机译：肥胖中的代谢表型：脂肪量，体脂分布和脂肪组织功能

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

摘要

著录项

相似文献

相关主题

期刊订阅