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首页> 外文期刊>Open Journal of Urology >Effects of Teriparatide and Aerobic Exercise on Lumbar Spine Microstructure in Ovariectomized and Tail-Suspended Rats
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Effects of Teriparatide and Aerobic Exercise on Lumbar Spine Microstructure in Ovariectomized and Tail-Suspended Rats

机译：Teriparatide和有氧运动对卵巢切除和尾悬浮大鼠腰椎微观结构的影响

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O steoporosis is an increasingly prevalent malady of the elderly that is associated with bone fragility and increased risk of fractures. Osteoporosis treatments focus on restoring bone strength and quality. Teriparatide (TPTD) is a therapeutic agent that has been shown to increase bone strength by improving the volume and connectivity of trabecular bone. Exercise is also known to have pro-osteogenic effects. Here we used a rat model of severe osteoporosis (ovariectomized and tail-suspension) to evaluate th e effects of TPTD, exercise and a combination of TPTD and exercise on the microstructure of trabecular bone. TPTD mono-therapy and TPTD combined with exercise treatment significantly increased bone mineral density (BMD) in the whole body . Micro-computed tomography analysis revealed that a combination of exercise and TPTD treatment significantly decreased bone surface to volume and trab ecular separation compared with those of the control and exercise groups. Node-strut analysis indicated that exercise or TPTD alone did not affect trabecular bone connectivity. However, the combination of exercise and TPTD treatment significantly decreased measures of tra becular bone connectivity (node number) that are consistent with a transition from rod-like to plate-like of trabecular bone microstructures. The combination treatment with exercise and TPTD improved microstructure of trabecular bone in the OVX and tail-suspended rats. These results indicate that combining exercise with TPTD represents a viable means to improve cancellous bone strength in osteoporosis populations.
机译：o稳定疏松症是老年人越来越普遍的疾病，与骨脆性相关，骨折的风险增加。骨质疏松症治疗焦点是恢复骨骼强度和质量。 Teriparatide（TPTD）是一种治疗剂，已经显示通过提高小梁骨的体积和连通性来增加骨强度。尚已知运动具有促求骨质效应。在这里，我们使用了严重骨质疏松症（卵巢切除和尾悬浮）的大鼠模型，以评估TPTD，运动和TPTD和运动组合对小梁骨的微观结构的影响。 TPTD单疗法和TPTD结合运动治疗，在全身中显着增加了骨矿物密度（BMD）。微型计算机断层扫描分析显示，与对照和运动组相比，运动和TPTD治疗的组合显着降低了骨表面和Trab Emetration的骨表面。节点Strut分析表明，单独的运动或TPTD不影响小梁骨连接。然而，运动和TPTD治疗的组合显着降低了与从杆状骨微观结构的杆状到板状过渡到板状的过渡的TRA骨骼连接（节点数）的措施显着降低。锻炼和TPTD的组合治疗和TPTD改善了OVX和尾悬浮大鼠的小梁骨的微观结构。这些结果表明，与TPTD的锻炼相结合代表了改善骨质疏松症群中的松质骨强度的可行方法。

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