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首页> 外文期刊>Open access Emergency Medicine >Serum Cleaved Tau Protein and Clinical Outcome in Patients with Minor Head Trauma
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Serum Cleaved Tau Protein and Clinical Outcome in Patients with Minor Head Trauma

机译：血清裂解Tau蛋白和患者患者的临床结果

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Introduction: Minor head trauma is due to the transfer of a mechanical energy to the brain caused by a traumatic event. The present study was accomplished aiming to investigate the cleaved tau protein (CTP) as a brain injury biomarker among patients with minor head trauma. Patients and Methods: This observational study was performed on patients with minor head trauma in 2017 who referred to emergency department of Imam Khomeini Hospital and Golestan Hospital of Ahvaz, Iran. The patients over the age of 16 years old with minor head trauma, who had computed tomography (CT) scan at most 10 hrs after the incident, and consented to participate in the study, were enrolled. C-tau evaluation was performed by the enzyme-linked immunosorbent assay (ELISA) method with monoclonal antibodies detecting the C-tau marker. Investigation of the injury after 3 months of minor head trauma was conducted using a post-concussion syndrome questionnaire (RPCS). Results: In this study, 86 patients were evaluated. CTP was positive in 14% of the patients and the results revealed that there was a significant relationship between traumatic brain injury (TBI) and positive CTP (p 0.0001). The CTP had a sensitivity and specificity of, respectively, 92% and 100% in detecting intracranial trauma. In addition, positive and negative predictive powers for this marker were 100% and 98%, respectively. Conclusion: In general, contrary to previous studies, the findings of this study suggest that evaluation of the CTP levels can be a strong biomarker with high sensitivity and specificity in detecting TBI.
机译：简介：次要头部创伤是由于机械能转移到由创伤事件引起的大脑。完成了本研究的目的是将切割的Tau蛋白（CTP）作为脑损伤的脑损伤生物标志物进行患者，患者患有轻微的头部创伤患者。患者及方法：对2017年患有伊曼奥姆·霍梅尼医院和伊朗古尔斯坦医院的急诊部门的患有急救症的患者进行了该观察研究。 16岁以上的患者，在事件中最多10小时的次次患者进行了次要的头发创伤（CT）扫描，并同意参加该研究。 C-TAU评价由酶联免疫吸附测定（ELISA）方法进行，用检测C-Tau标记物的单克隆抗体进行。使用后肠道综合征调查问卷（RPC）进行3个月的小头创伤后损伤调查。结果：在本研究中，评估了86名患者。 CTP在14％的患者中是阳性的，结果表明，创伤性脑损伤（TBI）和阳性CTP之间存在显着关系（P <0.0001）。 CTP在检测颅内创伤中分别具有92％和100％的敏感性和特异性。此外，该标记的阳性和阴性预测力分别为100％和98％。结论：一般来说，与先前的研究相反，本研究的结果表明CTP水平的评估可以是具有高灵敏度和检测TBI的敏感性和特异性的强生物标志物。

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