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首页> 外文期刊>Sao Paulo Medical Journal >Does Enoxaparin treatment have any effects on the placenta in women with unexplained histories of habitual abortion? A case control study
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Does Enoxaparin treatment have any effects on the placenta in women with unexplained histories of habitual abortion? A case control study

机译：甲氧基萘治疗是否对孕妇的胎盘有任何影响，具有无法解释的习惯性堕胎的历史？案例控制研究

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BACKGROUND: It is very common to offer low molecular weight heparin (LMWH) medications to women with unexplained habitual abortion, to increase the livebirth rate. Although no benefit from LMWH has been clearly demonstrated, examination of the effects of enoxaparin on placental structure is lacking. OBJECTIVE: To assess placental structural changes in pregnancies treated with enoxaparin, compared with controls. DESIGN AND SETTING: Case-control study in an obstetrics and gynecology unit of a tertiary-level university hospital in Turkey. METHODS: Forty patients who had had term pregnancies and live births but also histories of habitual abortion were recruited for this study. Placentas were sampled using a systematic random sampling method. Tissue samples were obtained, embedded and sectioned for routine histological analyses. Hematoxylin and eosin staining was used. Surface area and length estimates from placental components were evaluated by using Image J. Cell proliferation and apoptosis were also assessed via immunohistochemistry. RESULTS: There were no significant differences between the groups regarding maternal age, abortion rate, birth weight or gestational age. Comparison of the enoxaparin and control groups showed that there were no significant differences in terms of surface area and ratios of placental components. We found that Bcl-2 was generally expressed at high levels in the enoxaparin group, while there was no difference in terms of Ki-67 between the groups. CONCLUSIONS: This study demonstrates that enoxaparin did not show any significant effect on the placental structure of cases that had histories of habitual abortion.
机译：背景：提供低分子量肝素（LMWH）药物对妇女具有无法解释的习惯性堕胎的妇女是非常常见的，以增加腰生率。尽管已经清楚地证明了LMWH的任何益处，但缺乏对釉质结构对胎盘结构的影响。目的：评价依诺帕林治疗妊娠的胎盘结构变化，与对照相比。设计与环境：土耳其三级大学医院产科和妇科单位的病例对照研究。方法：招募了患有术语和活产的四十名患者，还招募了习惯性堕胎的历史。使用系统随机取样方法对胎盘进行取样。获得，嵌入和切割组织样品以常规组织学分析。使用苏木精和曙红染色。通过使用Image J.细胞增殖和细胞凋亡，通过免疫组织化学评估来自胎盘组分的表面积和长度估计。结果：孕产妇年龄，堕胎率，出生体重或孕龄之间没有显着差异。烯脱蒿素和对照组的比较表明，胎盘组分的表面积和比例没有显着差异。我们发现Bcl-2通常在脑诺拉帕林基团的高水平表达，而基团之间的Ki-67则没有差异。结论：本研究表明，伊诺帕林没有对具有习惯性堕胎历史的病例的胎盘结构没有任何显着影响。

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