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首页> 外文期刊>ScientificWorldJournal >Evaluation of Skin Permeation and Analgesic Activity Effects of Carbopol Lornoxicam Topical Gels Containing Penetration Enhancer
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Evaluation of Skin Permeation and Analgesic Activity Effects of Carbopol Lornoxicam Topical Gels Containing Penetration Enhancer

机译：含有渗透增强剂的Carbopol Lornoxicam局部凝胶的皮肤渗透和镇痛活动的评价

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摘要

The current study was designed to develop a topical gel formulation for improved skin penetration of lornoxicam (LOR) for enhancement of its analgesic activity. Moreover, the effect of different penetration enhancers on LOR was studied. The LOR gel formulations were prepared by using hydroxylpropyl methylcellulose (HPMC) and carbopol. The carbopol gels in presence of propylene glycol (PG) and ethanol were developed. The formulated gels were characterized for pH, viscosity, and LOR release using Franz diffusion cells. Also,in vitroskin permeation of LOR was conducted. The effect of hydroxypropylβ-cyclodextrin (HPβ-CD), beta-cyclodextrin (β-CD), Tween 80, and oleic acid on LOR permeation was evaluated. The optimized LOR gel formulation (LORF8) showed the highest flux (14.31 μg/cm2/h) with ER of 18.34 when compared to LORF3. Incorporation of PG and HPβ-CD in gel formulation (LORF8) enhanced the permeation of LOR significantly. It was observed that LORF3 and LORF8 show similar analgesic activity compared to marketed LOR injection (Xefo). This work shows that LOR can be formulated into carbopol gel in presence of PG and HPβ-CD and may be promising in enhancing permeation.
机译：目前的研究旨在开发局部凝胶配方，以改善林昔康（LOR）的皮肤渗透以提高其镇痛活性。此外，研究了不同渗透增强剂对LOR的影响。通过使用羟丙基甲基纤维素（HPMC）和Carbopol制备LOR凝胶制剂。开发出在丙二醇（PG）和乙醇存在下的Carbopol凝胶。配制的凝胶表征用于使用Franz扩散电池的pH，粘度和释放释放。此外，在玻璃皮肤中进行了LOR的渗透。评价羟丙基β-环糊精（HPβ-CD），β-环糊精（β-CD），吐温80和油酸对LOR渗透的影响。优化的LOR凝胶配方（LORF8）显示与LORF3相比的18.34的最高助焊剂（14.31μg/ cm 2 / h）。在凝胶制剂中掺入PG和HPβ-CD（LORF8）显着增强了LOR的渗透性。观察到Lorf3和Lorf8与市场上的LOR注射（XEFO）相比表现出类似的镇痛活性。这项工作表明，在PG和HPβ-CD存在下，可以将LOR配制到Carbopol凝胶中，并且可能在增强渗透方面具有很大的观点。

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