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首页> 外文期刊>Stroke Research and Treatment >Autologous Bone Marrow Mononuclear Cells Intrathecal Transplantation in Chronic Stroke
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Autologous Bone Marrow Mononuclear Cells Intrathecal Transplantation in Chronic Stroke

机译：自体骨髓单核细胞在慢性中风中的鞘内移植

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Cell therapy is being widely explored in the management of stroke and has demonstrated great potential. It has been shown to assist in the remodeling of the central nervous system by inducing neurorestorative effect through the process of angiogenesis, neurogenesis, and reduction of glial scar formation. In this study, the effect of intrathecal administration of autologous bone marrow mononuclear cells (BMMNCs) is analyzed on the recovery process of patients with chronic stroke. 24 patients diagnosed with chronic stroke were administered cell therapy, followed by multidisciplinary neurorehabilitation. They were assessed on functional independence measure (FIM) objectively, along with assessment of standing and walking balance, ambulation, and hand functions. Out of 24 patients, 12 improved in ambulation, 10 in hand functions, 6 in standing balance, and 9 in walking balance. Further factor analysis was done. Patients of the younger groups showed higher percentage of improvement in all the areas. Patients who underwent cell therapy within 2 years after the stroke showed better changes. Ischemic type of stroke had better recovery than the hemorrhagic stroke. This study demonstrates the potential of autologous BMMNCs intrathecal transplantation in improving the prognosis of functional recovery in chronic stage of stroke. Further clinical trials are recommended. This trial is registered withNCT02065778.
机译：细胞疗法在中风的管理中被广泛探讨，并表现出巨大的潜力。已经证明，通过血管生成，神经发生和胶质瘢痕形成的减少来诱导神经医生效果来帮助重塑中枢神经系统。在该研究中，对慢性卒中患者的恢复过程分析了自体骨髓单核细胞（BMMNC）的鞘内施用的影响。 24例诊断患有慢性中风的患者进行细胞疗法，然后进行多学科神经孢子率。他们客观地对功能独立措施（FIM）进行了评估，以及对常设和行走平衡，手动和手函数的评估。在24名患者中，12名患者在救护车中有所改善，手动职能10，稳定6人，行走平衡9人。进一步的因子分析完成。较年轻的群体患者在所有领域的改善百分比较高。在中风后2年内接受细胞疗法的患者表现出更好的变化。缺血类型的中风比出血性卒中具有更好的恢复。本研究表明了自体BMMNC鞘内移植在提高中风慢性阶段功能恢复预后的潜力。建议进一步的临床试验。此试验在NCT02065778中注册。

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