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首页> 外文期刊>Patient Preference and Adherence >Effects on caregiver burden of a donepezil hydrochloride dosage increase to 10 mg/day in?patients with Alzheimer’s disease
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Effects on caregiver burden of a donepezil hydrochloride dosage increase to 10 mg/day in?patients with Alzheimer’s disease

机译：对盐酸多奈哌齐的药剂负担的影响增加至10毫克/天？阿尔茨海默病的患者

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Background: In this study, we evaluated changes in functioning and caregiver burden in Alzheimer’s disease (AD) patients after a dosage increase that was made based on pharmacists’ evaluation of AD patients’ behavior in daily life. Methods: Pharmacists used a checklist, a questionnaire, and the Repetitive Saliva -Swallowing Test (RSST) to gather data on the daily life of AD patients taking donepezil 5 mg/day and their caregivers. In 27 cases, pharmacists suggested a dosage change to 10 mg/day to AD patients’ physicians. Pharmacists then evaluated these patients for 16 weeks after the increase to determine changes in functional assessment staging, caregiver burden, and swallowing function. Results: During the 16-week study, 20 of the 27 patients showed at least one-stage improvement in relation to the five assessed aspects of daily life (time/place, speech, bathing, dressing, and toileting). The mean score for caregiver burden due to personal strain was significantly lower after the dosage increase than before (5.15±3.76 at baseline; from 3.89±3.42 at week 4 to 3.59±3.90 at week 16; P<0.05), as was the mean score due to role strain (2.19±2.80 at baseline; 1.56±2.64 at week 8; P<0.05). After the dosage increase, the impaired swallowing function that accompanies AD was improved in the patients with swallowing problems, as indicated by a higher mean RSST score (1.22±0.67 at baseline; from 2.78±1.72 at week 4 to 2.78±1.79 at week 16; P<0.05). Conclusion: The dosage increase not only decreased caregiver burden, but also appeared to improve impaired swallowing function. Medication therapy management by pharmacists of AD patients, including the use of a checklist, contributed to the correct use of donepezil and improved quality of life for caregivers.
机译：背景：在这项研究中，我们在基于药剂师对日常生活中的AD患者行为的评估后的剂量增加后，评估了阿尔茨海默病（AD）患者的功能和照顾者负担的变化。方法：药剂师使用清单，调查问卷和重复的唾液 - 软化试验（RSST）来收集关于服用Deppezil / Day及其护理人员的AD患者日常生活的数据。在27例之前，药剂师建议剂量变化至10毫克/天至AD患者的医生。然后药剂师在增加后7周评估这些患者，以确定功能评估分期，护理人员负担和吞咽功能的变化。结果：在16周的研究中，27名患者中的20例表现出至少有一个阶段的日常生活中五个评估方面的改进（时间/地点，语音，沐浴，敷料和厕所）。由于个人菌株在剂量增加而不是之前（基线时5.15±3.76，在第16周，第16周的第3.59±3.90至3.59±3.90，因此，在剂量增加后，护理人员负担的平均得分显着降低（5.15±3.42至3.59±3.90; P <0.05），就像平均值一样由于作用菌株（基线2.19±2.80;每周8.56±2.64; P <0.05）。在剂量增加后，伴随着吞咽问题的吞咽函数受损的吞咽功能，如吞咽问题的提高，如较高的平均RSST分数（1.22±0.67在基线1.22±1.72，每周4到2.78±1.79 ; p <0.05）。结论：剂量不仅减少了照顾者负担，还似乎似乎改善了吞咽障碍。 AD患者药剂师的药物治疗管理，包括使用清单，有助于正确使用Dentpezil，并改善护理人员的生活质量。

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