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Adherence and persistence to typical and atypical antipsychotics in the naturalistic treatment of patients with schizophrenia

机译：精神分裂症患者自然治疗中典型和非典型抗精神病药的依从性和持久性

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Objective: To compare adherence and persistence to typical versus atypical antipsychotics and between specific atypical agents in the usual care of schizophrenia and to examine the association between adherence and persistence.Method: Data were drawn from a 3-year prospective, nonrandomized, noninterventional study of schizophrenia conducted during 1997–2003. Initiators on haloperidol, risperidone, olanzapine, quetiapine, and clozapine with at least 1 year of follow-up were included (n = 878). Adherence (Medication Possession Ratio, MPR) and persistence (time to all-cause medication discontinuation) were assessed using medical record prescription information. Analyses employed multivariate statistics adjusted for group differences.Results: Overall, 58% of the patients were deemed adherent (MPR >80%). Adherence rates were higher: for atypical (59.4%) than typical antipsychotics (34.5%, p < 0.001), for clozapine (77%) than each comparator excluding olanzapine (p < 0.01), and for olanzapine (64%) than risperidone (57%, p = 0.027) and quetiapine (52%, p = 0.019). Differences between risperidone and quetiapine were not statistically significant. Adherence and persistence were highly correlated (r = 0.957, p
机译：目的：将依从性和持续性与典型的非典型抗精神病药和特定的非典型药物与精神分裂症常用的特定非典型药物进行比较，并审查遵守与持久性之间的关联。方法：数据来自3年的前瞻性，非扫描，非行动研究精神分裂症在1997 - 2003年进行。包括氟哌啶醇，丙酮酮，奥氮平，喹硫碱和氯氮平的引发剂，包括至少1年的随访时间（n = 878）。使用医疗记录处方信息评估依从性（药物占有率，MPR）和持续性（持续到全部导致药物停止）。分析适用于组差异调整的多变量统计数据。结果：总体而言，58％的患者被视为粘附（MPR> 80％）。依从性率更高：对于非典型（59.4％）而不是典型的抗精神病药（34.5％，P <0.001），用于氯氮平（77％），而不是另外的每比较剂，不包括奥氮藻（P <0.01），以及奥氮翼（64％）而不是Risperidone（ 57％，p = 0.027）和喹硫碱（52％，p = 0.019）。立妥酮和喹啉之间的差异在统计学上没有统计学意义。依从性和持久性高度相关（r = 0.957，p <0.001）。结论：在常规护理精神分裂症中，药物粘附和持续性似乎具有高度相关性，并且在典型和非典型抗精神病学和非典型药物之间具有显着差异。抗精神病的选择可能在患者的坚持和持续存在于抗精神病药的依恋中起着有意义的作用。

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